Alpha-L-fucosidase

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In enzymology, an alpha-L-fucosidase (EC 3.2.1.51) is an enzyme that catalyzes the chemical reaction

an alpha-L-fucoside + H₂O $\rightleftharpoons$ L-fucose + an alcohol

Thus, the two substrates of this enzyme are alpha-L-fucoside and H₂O, whereas its two products are L-fucose and alcohol.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-L-fucoside fucohydrolase. This enzyme is also called alpha-fucosidase. This enzyme participates in n-glycan degradation and glycan structures - degradation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1HL8, 1HL9, and 1ODU.

[edit] References

IUBMB entry for 3.2.1.51
BRENDA references for 3.2.1.51 (Recommended.)
PubMed references for 3.2.1.51
PubMed Central references for 3.2.1.51
Google Scholar references for 3.2.1.51
Levvy GA and McAllan A (1961). "Mammalian fucosidases. 2. alpha-L-Fucosidase". Biochem. J. 80: 435–439.
Reglero A, Cabezas JA (1976). "Glycosidases of molluscs. Purification and properties of alpha-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66: 379–87. doi:10.1111/j.1432-1033.1976.tb10527.x. PMID 7458.
Tanaka K, Nakano T, Noguchi S, Pigman W (1968). "Purification of alpha-L-fucosidase of abalone livers". Arch. Biochem. Biophys. 126: 624–33. doi:10.1016/0003-9861(68)90449-9. PMID 5672520.