Alpha-7 nicotinic receptor

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The alpha-7 nicotinic receptor (α7)₅ is a type of nicotinic acetylcholine receptor, consisting entirely of α7 subunits ^[1].

It is located in the brain, where activation yields post- and presynaptic excitation^[1], mainly by increased Ca²⁺ permeability.

[edit] Agonists

Nicotinic agonists for this receptor include:

• epibatidine
• dimethylphenylpiperazinium
• GTS-21

[edit] Antagonists

• mecamylamine
• α-bungarotoxin

• α-conotoxin ArIB[V11L,V16D]^[2]

[edit] References

1. ^ ^{a b} Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 138.
2. ^ Whiteaker P, Christensen S, Yoshikami D, Dowell C, Watkins M, Gulyas J, Rivier J, Olivera BM, McIntosh JM. Discovery, synthesis, and structure activity of a highly selective alpha7 nicotinic acetylcholine receptor antagonist.Biochemistry. 2007 Jun 5;46(22):6628-38. http://pubs.acs.org/cgi-bin/abstract.cgi/bichaw/2007/46/i22/abs/bi7004202.html

v • d • e Ion channel, receptor: ligand-gated ion channels Cys-loop receptors 5-HT/serotonin: 5-HT3 (A) GABA: GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ2, γ3, δ, ε, π), GABA C (ρ1, ρ2) Glycine: α1, α2, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)2(β2)3, (α7)5, Ganglion type, Muscle type) Ionotropic glutamates AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D) ATP-gated channels Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)