Alpha-4 beta-2 nicotinic receptor

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The alpha-4 beta-2 nicotinic receptor ((α4)₂(β2)₃) is a type of nicotinic acetylcholine receptor, consisting of α4 and β2 subunits^[1].

It is located in the brain, where activation yields post- and presynaptic excitation^[1], mainly by increased Na⁺ and K⁺ permeability.

[edit] Agonists

Nicotinic agonists for this receptor include:

• nicotine
• epibatidine
• acetylcholine
• cytosine
• ABT-089
• ABT-418
• dianicline
• ispronicline
• rivanicline
• tebanicline
• varenicline

[edit] Antagonists

• mecamylamine
• methylaconitine
• α-conotoxin

[edit] References

v • d • e Ion channel, receptor: ligand-gated ion channels Cys-loop receptors 5-HT/serotonin: 5-HT3 (A) GABA: GABA A (α1, α2, α3, α4, α5, α6, β1, β2, β3, γ2, γ3, δ, ε, π), GABA C (ρ1, ρ2) Glycine: α1, α2, β Nicotinic acetylcholine: α1, α2, α3, α4, α5, α7, α9, β1, β2, β3, β4, δ, ε, combinations ((α4)2(β2)3, (α7)5, Ganglion type, Muscle type) Ionotropic glutamates AMPA (1, 2, 3, 4) - Kainate (1, 2, 3, 5) - NMDA (1, 2A, 2B, 2C, 2D) ATP-gated channels Purinergic receptors: P2X (1, 2, 3, 4, 5, 6, 7)