Alpha,alpha-trehalose-phosphate synthase (UDP-forming)

From Wikipedia, the free encyclopedia

In enzymology, an alpha,alpha-trehalose-phosphate synthase (UDP-forming) (EC 2.4.1.15) is an enzyme that catalyzes the chemical reaction

UDP-glucose + D-glucose 6-phosphate UDP + alpha,alpha-trehalose 6-phosphate

Thus, the two substrates of this enzyme are UDP-glucose and D-glucose 6-phosphate, whereas its two products are UDP and alpha,alpha'-trehalose 6-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase. Other names in common use include UDP-glucose-glucose-phosphate glucosyltransferase, trehalosephosphate-UDP glucosyltransferase, UDP-glucose-glucose-phosphate glucosyltransferase, alpha,alpha-trehalose phosphate synthase (UDP-forming), phosphotrehalose-uridine diphosphate transglucosylase, trehalose 6-phosphate synthase, trehalose 6-phosphate synthetase, trehalose phosphate synthase, trehalose phosphate synthetase, trehalose phosphate-uridine diphosphate glucosyltransferase, trehalose-P synthetase, transglucosylase, and uridine diphosphoglucose phosphate glucosyltransferase. This enzyme participates in starch and sucrose metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1GZ5, 1UQT, and 1UQU.

[edit] References

• IUBMB entry for 2.4.1.15
• BRENDA references for 2.4.1.15 (Recommended.)
• PubMed references for 2.4.1.15
• PubMed Central references for 2.4.1.15
• Google Scholar references for 2.4.1.15
• CABIB E, LELOIR LF (1958). "The biosynthesis of trehalose phosphate". J. Biol. Chem. 231: 259–75. PMID 13538966. 
• CANDY DJ, KILBY BA (1961). "The biosynthesis of trehalose in the locust fat body". Biochem. J. 78: 531–6. PMID 13690400. 
• LORNITZO FA, GOLDMAN DS (1964). "PURIFICATION AND PROPERTIES OF THE TRANSGLUCOSYLASE INHIBITOR OF MYCOBACTERIUM TUBERCULOSIS". J. Biol. Chem. 239: 2730–4. PMID 14216421. 
• MURPHY TA, WYATT GR (1965). "THE ENZYMES OF GLYCOGEN AND TREHALOSE SYNTHESIS IN SILK MOTH FAT BODY". J. Biol. Chem. 240: 1500–8. PMID 14285483. 

[edit] External links

The CAS registry number for this enzyme class is 9030-07-3.

• IUBMB entry for 2.4.1.15

• KEGG entry for 2.4.1.15

• BRENDA entry for 2.4.1.15

• NiceZyme view of 2.4.1.15

• EC2PDB: PDB structures for 2.4.1.15

• PRIAM entry for 2.4.1.15

• PUMA2 entry for 2.4.1.15

• IntEnz: Integrated Enzyme entry for 2.4.1.15

• MetaCyc entry for 2.4.1.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0003825: alpha,alpha-trehalose-phosphate synthase (UDP-forming)

• AMIGO entry for GO code 0003825: alpha,alpha-trehalose-phosphate synthase (UDP-forming)