Alpha,alpha-trehalase

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In enzymology, an alpha,alpha-trehalase (EC 3.2.1.28) is an enzyme that catalyzes the chemical reaction

alpha,alpha-trehalose + H₂O 2 D-glucose

Thus, the two substrates of this enzyme are alpha,alpha-trehalose and H₂O, whereas its product is D-glucose.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha,alpha-trehalose glucohydrolase. This enzyme is also called trehalase. This enzyme participates in starch and sucrose metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2JF4 and 2JG0.

[edit] References

• IUBMB entry for 3.2.1.28
• BRENDA references for 3.2.1.28 (Recommended.)
• PubMed references for 3.2.1.28
• PubMed Central references for 3.2.1.28
• Google Scholar references for 3.2.1.28
• KALF GF, RIEDER SV (1958). "The purification and properties of trehalase". J. Biol. Chem. 230: 691–8. PMID 13525386. 
• Myrback K and Ortenblad B (1937). "Trehalose und Hefe. II. Trehalasewirkung von Hefepraparaten". Biochem. Z. 291: 61–69. 

[edit] External links

The CAS registry number for this enzyme class is 9025-52-9.

• IUBMB entry for 3.2.1.28

• KEGG entry for 3.2.1.28

• BRENDA entry for 3.2.1.28

• NiceZyme view of 3.2.1.28

• EC2PDB: PDB structures for 3.2.1.28

• PRIAM entry for 3.2.1.28

• PUMA2 entry for 3.2.1.28

• IntEnz: Integrated Enzyme entry for 3.2.1.28

• MetaCyc entry for 3.2.1.28

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004555: alpha,alpha-trehalase

• AMIGO entry for GO code 0004555: alpha,alpha-trehalase