ALOXE3

From Wikipedia, the free encyclopedia

Arachidonate lipoxygenase 3

Identifiers

ALOXE3; MGC119694; MGC119695; MGC119696

External IDs

OMIM: 607206 MGI: 1345140 HomoloGene: 8013

Gene ontology
Molecular Function:	• iron ion binding • lipoxygenase activity • oxidoreductase activity • metal ion binding
Biological Process:	• electron transport • leukotriene biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021628 (mRNA)
NP_067641 (protein)

NM_011786 (mRNA)
NP_035916 (protein)

Location

Chr 17: 7.94 - 7.96 Mb

Chr 11: 68.94 - 68.97 Mb

Pubmed search

[1]

[2]

Arachidonate lipoxygenase 3, also known as ALOXE3, is a human gene.^[1]

The leukotrienes constitute a group of arachidonic acid-derived compounds with biologic activities suggesting important roles in inflammation and immediate hypersensitivity. These compounds are catabolized, in part, by lipoxygenases. Epidermis-type lipoxygenases, a distinct subclass within the multigene family of mammalian lipoxygenases, are novel isoenzymes isolated from human and mouse skin including human ALOX15B (MIM 603697), human and mouse ALOX12B (MIM 603741), mouse 8S-LOX, and mouse e-LOX-3.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ALOXE3 arachidonate lipoxygenase 3.

[edit] Further reading

Yu Z, Schneider C, Boeglin WE, Brash AR (2007). "Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha.". Lipids 42 (6): 491-7. doi:10.1007/s11745-007-3054-4. PMID 17436029.
Lesueur F, Bouadjar B, Lefèvre C, et al. (2007). "Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.". J. Invest. Dermatol. 127 (4): 829-34. doi:10.1038/sj.jid.5700640. PMID 17139268.
Yu Z, Schneider C, Boeglin WE, Brash AR (2007). "Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin.". Arch. Biochem. Biophys. 455 (2): 188-96. doi:10.1016/j.abb.2006.09.002. PMID 17045234.
Yu Z, Schneider C, Boeglin WE, Brash AR (2005). "Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3.". Biochim. Biophys. Acta 1686 3: 238-47. doi:10.1016/j.bbalip.2004.10.007. PMID 15629692.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Jobard F, Lefèvre C, Karaduman A, et al. (2002). "Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1.". Hum. Mol. Genet. 11 (1): 107-13. PMID 11773004.
Krieg P, Marks F, Fürstenberger G (2001). "A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.". Genomics 73 (3): 323-30. doi:10.1006/geno.2001.6519. PMID 11350124.