ALOX15

From Wikipedia, the free encyclopedia

Arachidonate 15-lipoxygenase

Identifiers

ALOX15; 15-LOX2

External IDs

OMIM: 152392 MGI: 87997 HomoloGene: 44935

Gene ontology
Molecular Function:	• iron ion binding • lipoxygenase activity • oxidoreductase activity • metal ion binding • arachidonate 15-lipoxygenase activity
Cellular Component:	• plasma membrane
Biological Process:	• electron transport • lipid metabolic process • leukotriene metabolic process • inflammatory response • leukotriene biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001131480 (mRNA)
XP_001131480 (protein)

NM_009660 (mRNA)
NP_033790 (protein)

Location

Chr 17: 4.48 - 4.49 Mb

Chr 11: 70.16 - 70.17 Mb

Pubmed search

[1]

[2]

Arachidonate 15-lipoxygenase, also known as ALOX15, is a human gene.

[edit] Further reading

Kelavkar U, Glasgow W, Eling TE (2003). "The effect of 15-lipoxygenase-1 expression on cancer cells.". Current urology reports 3 (3): 207–14. PMID 12084190.
Sigal E, Dicharry S, Highland E, Finkbeiner WE (1992). "Cloning of human airway 15-lipoxygenase: identity to the reticulocyte enzyme and expression in epithelium.". Am. J. Physiol. 262 (4 Pt 1): L392–8. PMID 1566855.
Funk CD, Funk LB, FitzGerald GA, Samuelsson B (1992). "Characterization of human 12-lipoxygenase genes.". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3962–6. PMID 1570320.
Izumi T, Rådmark O, Jörnvall H, Samuelsson B (1992). "Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes.". Eur. J. Biochem. 202 (3): 1231–8. PMID 1662607.
Conrad DJ, Kuhn H, Mulkins M, et al. (1992). "Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 217–21. PMID 1729692.
Lei ZM, Rao CV (1992). "The expression of 15-lipoxygenase gene and the presence of functional enzyme in cytoplasm and nuclei of pregnancy human myometria.". Endocrinology 130 (2): 861–70. PMID 1733732.
Izumi T, Rådmark O, Samuelsson B (1991). "Purification of 15-lipoxygenase from human leukocytes, evidence for the presence of isozymes.". Adv. Prostaglandin Thromboxane Leukot. Res. 21A: 101–4. PMID 1825526.
Sloane DL, Leung R, Craik CS, Sigal E (1991). "A primary determinant for lipoxygenase positional specificity.". Nature 354 (6349): 149–52. doi:10.1038/354149a0. PMID 1944593.
Nadel JA, Conrad DJ, Ueki IF, et al. (1991). "Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells.". J. Clin. Invest. 87 (4): 1139–45. PMID 2010530.
Kroschwald P, Kroschwald A, Kühn H, et al. (1989). "Occurrence of the erythroid cell specific arachidonate 15-lipoxygenase in human reticulocytes.". Biochem. Biophys. Res. Commun. 160 (2): 954–60. PMID 2719708.
Sigal E, Nadel JA (1989). "Arachidonic acid 15-lipoxygenase and airway epithelium. Biologic effects and enzyme purification.". Am. Rev. Respir. Dis. 138 (6 Pt 2): S35–40. PMID 3202520.
Sigal E, Craik CS, Highland E, et al. (1989). "Molecular cloning and primary structure of human 15-lipoxygenase.". Biochem. Biophys. Res. Commun. 157 (2): 457–64. PMID 3202857.
Sigal E, Grunberger D, Craik CS, et al. (1988). "Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.". J. Biol. Chem. 263 (11): 5328–32. PMID 3356688.
Nassar GM, Morrow JD, Roberts LJ, et al. (1994). "Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.". J. Biol. Chem. 269 (44): 27631–4. PMID 7961680.
Kritzik MR, Ziober AF, Dicharry S, et al. (1997). "Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene.". Biochim. Biophys. Acta 1352 (3): 267–81. PMID 9224951.
Brinckmann R, Schnurr K, Heydeck D, et al. (1998). "Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme.". Blood 91 (1): 64–74. PMID 9414270.
Kelavkar U, Wang S, Montero A, et al. (1998). "Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes.". Mol. Biol. Rep. 25 (3): 173–82. PMID 9700053.
Roy B, Cathcart MK (1998). "Induction of 15-lipoxygenase expression by IL-13 requires tyrosine phosphorylation of Jak2 and Tyk2 in human monocytes.". J. Biol. Chem. 273 (48): 32023–9. PMID 9822675.
Kratky D, Lass A, Abuja PM, et al. (1999). "A sensitive chemiluminescence method to measure the lipoxygenase catalyzed oxygenation of complex substrates.". Biochim. Biophys. Acta 1437 (1): 13–22. PMID 9931410.
Kelavkar UP, Badr KF (1999). "Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene.". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4378–83. PMID 10200270.