Almotriptan

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Almotriptan
Systematic (IUPAC) name
N,N-dimethyl-2- [5-(pyrrolidin-1-ylsulfonylmethyl)- 1H-indol-3-yl]-ethanamine
Identifiers
CAS number 154323-57-6
ATC code N02CC05
PubChem 123606
DrugBank APRD00169
Chemical data
Formula C17H25N3O2S 
Mol. mass 335.465 g/mol
Pharmacokinetic data
Bioavailability 70%
Protein binding 35%
Metabolism  ?
Half life 3-4 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C(USA)

Legal status

Prescription only

Routes Oral

Almotriptan (Axert®, Almogran®) is a triptan drug discovered by Almirall Prodesfarma and licensed to Ortho-McNeil for the treatment of migraine headaches. It is available in strengths of 6.25 and 12.5 mg as a tablet.

In the United States and Canada almotriptan is available under the name Axert® only by prescription. AXERT® for oral administration contains almotriptan malate equivalent to 6.25 or 12.5 mg of almotriptan. Each compressed tablet contains the following inactive ingredients: mannitol, cellulose, povidone, sodium starch glycolate, sodium stearyl fumarate, titanium dioxide, hypromellose, polyethylene glycol, propylene glycol, iron oxide (6.25 mg only), FD&C Blue No. 2 (12.5 mg only), and carnauba wax. The brand Almogran is used in Belgium, Finland, France, Germany, Italy, Portugal, Spain and the United Kingdom. Each 12.5 mg. tablet contains the following inactive ingredients: carnauba wax, hypromellose, indigo carmine (E132), macrogol 400, mannitol, microcrystalline cellulose, povidone, propylene glycol, sodium starch glycollate, sodium stearyl fumarate and titanium dioxide (E171).

[edit] Clinical uses

Almotriptan is indicated for the acute treatment of migraine with or without aura in adults.

[edit] External links

  • R&D page by Almirall Prodesfarma
  • Axert Official homepage by Ortho-McNeil
  • Axert prescribing information
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