Alkylglycerophosphoethanolamine phosphodiesterase
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In enzymology, an alkylglycerophosphoethanolamine phosphodiesterase (EC 3.1.4.39) is an enzyme that catalyzes the chemical reaction
- 1-alkyl-sn-glycero-3-phosphoethanolamine + H2O
1-alkyl-sn-glycerol 3-phosphate + ethanolamine
Thus, the two substrates of this enzyme are 1-alkyl-sn-glycero-3-phosphoethanolamine and H2O, whereas its two products are 1-alkyl-sn-glycerol 3-phosphate and ethanolamine.
This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is 1-alkyl-sn-glycero-3-phosphoethanolamine ethanolaminehydrolase. This enzyme is also called lysophospholipase D. This enzyme participates in ether lipid metabolism.
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[edit] Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1FJ2.
[edit] References
- IUBMB entry for 3.1.4.39
- BRENDA references for 3.1.4.39 (Recommended.)
- PubMed references for 3.1.4.39
- PubMed Central references for 3.1.4.39
- Google Scholar references for 3.1.4.39
- Wykle RL, Schremmer JM (1974). "A lysophospholipase D pathway in the metabolism of ether-linked lipids in brain microsomes". J. Biol. Chem. 249: 1742–6. PMID 4855486.
[edit] External links
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- The CAS registry number for this enzyme class is 62213-15-4.
[edit] Gene Ontology (GO) codes
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