Alkene monooxygenase

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In enzymology, an alkene monooxygenase (EC 1.14.13.69) is an enzyme that catalyzes the chemical reaction

propene + NADH + H⁺ + O₂ $\rightleftharpoons$ 1,2-epoxypropane + NAD⁺ + H₂O

The 4 substrates of this enzyme are propene, NADH, H⁺, and O₂, whereas its 3 products are 1,2-epoxypropane, NAD⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is alkene,NADH:oxygen oxidoreductase. This enzyme is also called alkene epoxygenase. This enzyme participates in tetrachloroethene degradation.

[edit] References

IUBMB entry for 1.14.13.69
BRENDA references for 1.14.13.69 (Recommended.)
PubMed references for 1.14.13.69
PubMed Central references for 1.14.13.69
Google Scholar references for 1.14.13.69
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Zhou NY, Jenkins A, Chan Kwo Chion CK, Leak DJ (1999). "The alkene monooxygenase from Xanthobacter strain Py2 is closely related to aromatic monooxygenases and catalyzes aromatic monohydroxylation of benzene, toluene, and phenol". Appl. Environ. Microbiol. 65: 1589–95. PMID 10103255.
Gallagher SC, Cammack R, Dalton H (1997). "Alkene monooxygenase from Nocardia corallina B-276 is a member of the class of dinuclear iron proteins capable of stereospecific epoxygenation reactions". Eur. J. Biochem. 247: 635–41. doi:10.1111/j.1432-1033.1997.00635.x. PMID 9266707.