Alkane 1-monooxygenase

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In enzymology, an alkane 1-monooxygenase (EC 1.14.15.3) is an enzyme that catalyzes the chemical reaction

octane + reduced rubredoxin + O₂ $\rightleftharpoons$ 1-octanol + oxidized rubredoxin + H₂O

The 3 substrates of this enzyme are octane, reduced rubredoxin, and O₂, whereas its 3 products are 1-octanol, oxidized rubredoxin, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with reduced iron-sulfur protein as one donor, and incorporation o one atom of oxygen into the other donor. The systematic name of this enzyme class is alkane,reduced-rubredoxin:oxygen 1-oxidoreductase. Other names in common use include alkane 1-hydroxylase, omega-hydroxylase, fatty acid omega-hydroxylase, alkane monooxygenase, 1-hydroxylase, and alkane hydroxylase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, arachidonic acid metabolism, and ppar signaling pathway. It employs one cofactor, heme.

[edit] References

IUBMB entry for 1.14.15.3
BRENDA references for 1.14.15.3 (Recommended.)
PubMed references for 1.14.15.3
PubMed Central references for 1.14.15.3
Google Scholar references for 1.14.15.3
Cardini G, Jurtshuk P (1970). "The enzymatic hydroxylation of n-octane by Corynebacterium sp strain 7E1C". J. Biol. Chem. 245: 2789–96. PMID 4317878.
McKenna EJ, Coon MJ (1970). "Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans". J. Biol. Chem. 245: 3882–9. PMID 4395379.
Peterson JA, Kusunose M, Kusunose E, Coon MJ (1967). "Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation". J. Biol. Chem. 242: 4334–40. PMID 4294330.