Aliphatic nitrilase

From Wikipedia, the free encyclopedia

In enzymology, an aliphatic nitrilase (EC 3.5.5.7) is an enzyme that catalyzes the chemical reaction

R-CN + 2 H₂O R-COOH + NH₃

Thus, the two substrates of this enzyme are R-CN and H₂O, whereas its two products are R-COOH and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in nitriles. The systematic name of this enzyme class is aliphatic nitrile aminohydrolase. This enzyme participates in styrene degradation.

[edit] References

• IUBMB entry for 3.5.5.7
• BRENDA references for 3.5.5.7 (Recommended.)
• PubMed references for 3.5.5.7
• PubMed Central references for 3.5.5.7
• Google Scholar references for 3.5.5.7
• Kobayashi M, Yanaka N, Nagasawa T, Yamada H (1992). "Primary structure of an aliphatic nitrile-degrading enzyme, aliphatic nitrilase, from Rhodococcus rhodochrous K22 and expression of its gene and identification of its active site residue". Biochemistry. 31: 9000–7. PMID 1390687. 
• Pace HC, Brenner C (2001). "The nitrilase superfamily: classification, structure and function". Genome. Biol. 2: REVIEWS0001. PMID 11380987. 

[edit] External links

The CAS registry number for this enzyme class is 9024-90-2.

• IUBMB entry for 3.5.5.7

• KEGG entry for 3.5.5.7

• BRENDA entry for 3.5.5.7

• NiceZyme view of 3.5.5.7

• EC2PDB: PDB structures for 3.5.5.7

• PRIAM entry for 3.5.5.7

• PUMA2 entry for 3.5.5.7

• IntEnz: Integrated Enzyme entry for 3.5.5.7

• MetaCyc entry for 3.5.5.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018762: aliphatic nitrilase

• AMIGO entry for GO code 0018762: aliphatic nitrilase