Alglucerase
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Alglucerase
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Systematic (IUPAC) name | |
Human Beta-glucocerebrosidase | |
Identifiers | |
CAS number | |
ATC code | A16 |
PubChem | ? |
DrugBank | |
Chemical data | |
Formula | C2532H3854N672O711S16 |
Mol. mass | 55597.4 g/mol |
Pharmacokinetic data | |
Bioavailability | ? |
Metabolism | ? |
Half life | 3.6–10.4 min |
Excretion | ? |
Therapeutic considerations | |
Pregnancy cat. |
? |
Legal status | |
Routes | ? |
Alglucerase is a modified form of human β-glucocerebrosidase where the non-reducing ends of the oligosaccharide chains have been terminated with mannose residues. Ceredase is a citrate buffered solution of Alglucerase manufactured by Genzyme Corporation from human placental tissue. It is given intravenously in the treatment of Type 1 Gaucher's disease although it has been largely replaced by Cerezyme which is produced by Recombinant DNA technology.
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