ALG1

From Wikipedia, the free encyclopedia

Asparagine-linked glycosylation 1 homolog (S. cerevisiae, beta-1,4-mannosyltransferase)

Identifiers

ALG1; HMAT1; HMT-1; HMT1

External IDs

OMIM: 605907 MGI: 2384774 HomoloGene: 5387

Gene ontology
Molecular Function:	• chitobiosyldiphosphodolichol beta-mannosyltransferase activity • transferase activity, transferring glycosyl groups
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane
Biological Process:	• protein amino acid glycosylation • biosynthetic process • lipopolysaccharide biosynthetic process

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_019109 (mRNA)
NP_061982 (protein)

NM_145362 (mRNA)
NP_663337 (protein)

Location

n/a

Chr 16: 5.15 - 5.16 Mb

Pubmed search

[1]

[2]

Asparagine-linked glycosylation 1 homolog (S. cerevisiae, beta-1,4-mannosyltransferase), also known as ALG1, is a human gene.^[1]

The biosynthesis of lipid-linked oligosaccharides is highly conserved among eukaryotes and is catalyzed by 14 glycosyltransferases in an ordered stepwise manner. Mannosyltransferase I (MT I) catalyzes the first mannosylation step in this process.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ALG1 asparagine-linked glycosylation 1 homolog (S. cerevisiae, beta-1,4-mannosyltransferase).

[edit] Further reading

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kranz C, Denecke J, Lehle L, et al. (2004). "Congenital disorder of glycosylation type Ik (CDG-Ik): a defect of mannosyltransferase I.". Am. J. Hum. Genet. 74 (3): 545-51. doi:10.1086/382493. PMID 14973782.
Schwarz M, Thiel C, Lübbehusen J, et al. (2004). "Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik.". Am. J. Hum. Genet. 74 (3): 472-81. doi:10.1086/382492. PMID 14973778.
Grubenmann CE, Frank CG, Hülsmeier AJ, et al. (2004). "Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik.". Hum. Mol. Genet. 13 (5): 535-42. doi:10.1093/hmg/ddh050. PMID 14709599.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Takahashi T, Honda R, Nishikawa Y (2000). "Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1.". Glycobiology 10 (3): 321-7. PMID 10704531.