Aldehyde dehydrogenase (NAD(P)+)

From Wikipedia, the free encyclopedia

In enzymology, an aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) is an enzyme that catalyzes the chemical reaction

an aldehyde + NAD(P)+ + H₂O $\rightleftharpoons$ an acid + NAD(P)H + H⁺

The 4 substrates of this enzyme are aldehyde, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are acid, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aldehyde:NAD(P)+ oxidoreductase. Other names in common use include aldehyde dehydrogenase [NAD(P)+], and ALDH. This enzyme participates in 5 metabolic pathways: glycolysis / gluconeogenesis, histidine metabolism, tyrosine metabolism, phenylalanine metabolism, and metabolism of xenobiotics by cytochrome p450.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1AD3, 1EYY, 1EZ0, and 2AMF.

[edit] References

IUBMB entry for 1.2.1.5
BRENDA references for 1.2.1.5 (Recommended.)
PubMed references for 1.2.1.5
PubMed Central references for 1.2.1.5
Google Scholar references for 1.2.1.5
Black S (1951). "Yeast aldehyde dehydrogenase". Arch. Biochem. Biophys. 34: 86–97. doi:10.1016/S0003-9861(51)80013-4.
Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 203-221.
KING TE, CHELDELIN VH (1956). "Oxidation of acetaldehyde by Acetobacter suboxydans". J. Biol. Chem. 220: 177–91. PMID 13319337.
Steinman CR, Jakoby WB (1967). "Yeast aldehyde dehydrogenase. I. Purification and crystallization". J. Biol. Chem. 242: 5019–23. PMID 4293780.
Tanenbaum SW (1956). "The metabolism of Acetobacter peroxidans. I. Oxidative enzymes". Biochim. Biophys. Acta 21: 335–342. doi:10.1016/0006-3002(56)90017-8.