ALDH3B2

From Wikipedia, the free encyclopedia

Aldehyde dehydrogenase 3 family, member B2

Identifiers

External IDs

OMIM: 601917

Gene ontology
Molecular Function:	• 3-chloroallyl aldehyde dehydrogenase activity • aldehyde dehydrogenase [NAD(P)+ activity] • oxidoreductase activity
Biological Process:	• alcohol metabolic process • aldehyde metabolic process • lipid metabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_000695 (mRNA)
NP_000686 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 11: 67.19 - 67.2 Mb

n/a

Pubmed search

[1]

n/a

Aldehyde dehydrogenase 3 family, member B2, also known as ALDH3B2, is a human gene.^[1]

This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: ALDH3B2 aldehyde dehydrogenase 3 family, member B2.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Hsu LC, Chang WC, Yoshida A (1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison.". Gene 189 (1): 89–94. PMID 9161417.
Hsu LC, Chang WC (1996). "Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family.". Gene 174 (2): 319–22. PMID 8890755.
Hsu LC, Chang WC, Lin SW, Yoshida A (1995). "Cloning and characterization of genes encoding four additional human aldehyde dehydrogenase isozymes.". Adv. Exp. Med. Biol. 372: 159–68. PMID 7484374.