ALDH1B1

From Wikipedia, the free encyclopedia

Aldehyde dehydrogenase 1 family, member B1

Identifiers

ALDH1B1; ALDH5; ALDHX; MGC2230

External IDs

OMIM: 100670 MGI: 1919785 HomoloGene: 68079

Gene ontology
Molecular Function:	• 3-chloroallyl aldehyde dehydrogenase activity • aldehyde dehydrogenase (NAD) activity • oxidoreductase activity
Cellular Component:	• mitochondrion
Biological Process:	• carbohydrate metabolic process • metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000692 (mRNA)
NP_000683 (protein)

NM_028270 (mRNA)
NP_082546 (protein)

Location

Chr 9: 38.38 - 38.39 Mb

Chr 4: 45.82 - 45.83 Mb

Pubmed search

[1]

[2]

Aldehyde dehydrogenase 1 family, member B1, also known as ALDH1B1, is a human gene.^[1]

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems.^[1]

[edit] References

^ ^a ^b Entrez Gene: ALDH1B1 aldehyde dehydrogenase 1 family, member B1.

[edit] Further reading

Yoshida A (1993). "Molecular genetics of human aldehyde dehydrogenase.". Pharmacogenetics 2 (4): 139–47. PMID 1306115.
Hsu LC, Chang WC (1991). "Cloning and characterization of a new functional human aldehyde dehydrogenase gene.". J. Biol. Chem. 266 (19): 12257–65. PMID 2061311.
Hiraoka LR, Hsu L, Hsieh CL (1995). "Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13.". Genomics 25 (1): 323–5. PMID 7774944.
Stewart MJ, Malek K, Xiao Q, et al. (1995). "The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme.". Biochem. Biophys. Res. Commun. 211 (1): 144–51. doi:10.1006/bbrc.1995.1789. PMID 7779080.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Sherman D, Davé V, Hsu LC, et al. (1994). "Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene.". Hum. Genet. 92 (5): 477–80. PMID 8244338.
Stewart MJ, Malek K, Crabb DW (1996). "Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues.". J. Investig. Med. 44 (2): 42–6. PMID 8689400.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Luo P, Wang A, Payne KJ, et al. (2007). "Intrinsic retinoic acid receptor alpha-cyclin-dependent kinase-activating kinase signaling involves coordination of the restricted proliferation and granulocytic differentiation of human hematopoietic stem cells.". Stem Cells 25 (10): 2628–37. doi:10.1634/stemcells.2007-0264. PMID 17628022.