Talk:Alcohol flush reaction

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[edit] Pepcid

Pepcid AC??

Has there been any real verification that Pepcid works?

[edit] problem sentence

"People affected by flushing may be inebriated more quickly than others, but there are other cases where the side effects prevent people with alchohol flush reaction have not been necessarily intolerant of alchohol but just seem to have an external indicator of drunkness."

I tried editing this only to find out that I have little idea what it's talking about. So I put it here, because if there is an important concept that I've mistakenly removed, you're welcome to clarify and re-insert the sentence. --Lux 06:09, 26 May 2006 (UTC)

[edit] proposed merge

By all means, go ahead. I searched for it, but didn't find it, probably because I included the word "disease", which I've added to the also known as so people can find it more easily if they are more familiar with the term, as I was. --Lux 06:19, 26 May 2006 (UTC)

Actually, no discussion is necessary. Since they refer to the same disease, a simple redirect, after the consequent merge, will work. I will do that now. Hold on. --Lux 07:07, 26 May 2006 (UTC)

[edit] disulf

In fact, disulfiram, also known as Antabuse, is used to treat alcoholism

this statement doesn't really have a sensible tone when "disulfiram" is mentioned for the first time in the article

Sensible tone?--Lux 02:00, 15 June 2006 (UTC)
In fact, disulfiram, also known as Antabuse, is used to treat alcoholism
The sentence above does not indicate, in any way, how disulfiram relates to anything in the article. The rest of the paragraph also does not adequately prove that disulfiram produces a flush reaction chemically identical to the article's subject. It's POV speculation and original research by the contributor of that section.

Antabuse is not "a leading treatment for alcoholism" at least in the US and the references give do not support such a claim. The drug is tangentally related as its site of action is the same enzyme that is responsible for the reaction the article is about. 151.112.57.22 21:16, 18 April 2007 (UTC)

[edit] histamines

probably why h2 blockers work... decreasing histamine release locally at the stomach and systematically


http://www.parkinson.org/site/pp.aspx?c=9dJFJLPwB&b=100073&printmode=1

Facial Flushing and Drugs
Certain drugs can cause the sudden or gradual appearance of a red, burning face. Any drug that releases histamine, vasoactive peptide (substance P), or prostaglandin can cause facial flushing. Examples of these types of drugs are:
Nitroglycerin
Nifedipine
Niacin
Vancomycin
Calcitonin
Ethanol
Monosodium Glutamate (MSG)
Disulfiram (Antabuse)
Corticotrophin-releasing Hormone

Twobrain 17:14, 15 June 2006 (UTC)


[edit] link 4 is busted

=D 17:20, 15 June 2006 (UTC)


[edit] Asian??

The second source attached to this article implicates only Chinise, Korean, and Japanese people. Shouldn't this be mentioned somewhere?

[edit] Non-Asians??

Myself, my mother and a good part of her family all experience this, though as far as I know they are entirely European. Is this a different condition or does this mutation occur in other ethnic groups?


I understand that it also affects people of Jewish descent. Is it possible that you're European jew? Ttchiem 06:23, 2 October 2006 (UTC)

i am also affected by this, none of my family are, just me!!!! i am half greek though? i dont get it...at all! im not asian just half european? explain?

Russians and Ukrainians also have this condition. Their genes came from the Mongolian conquests.

I think this just hit me for the first time today... I'm a non-Jewish Caucasian, and most of my ancestors came from Germanic countries and the British Isles. After three beers tonight, my face got really red, (except right around the eyes, where I suppose there are fewer capillaries), and I had red blotches on my neck and chest. I could also feel my carotid artery pulsing and my sinuses felt "stuffed." I actually had to take a few sprays of Afrin to relieve the congestion. I only hit upon this page once I recalled some of my ethnic-Asian college buddies would turn beet red after only a few drinks.

Weird, a couple of months ago I had developed a week-long episode of hives after a night of drinking and I feared I had developed an allergic reaction to alcohol. Maybe it's coming back?

Naturally people of any ethnic group may have the mutation but it is much more common in Asian populations. If there are other groups that are commonly affected find a source as people posting their reactions is clearly anecdotal. Also, as far as I know it is not possible to have an allergic reactions to EtOH but you may suffer from symptoms that resemble allergies from drinking.

[edit] Why asians?

The explanation part is only chemical... The interesting thing to explain about asian flush is why mainly people from sertain parts of asia are affected. A cultural explanaition would be much more interesting, if there are any theories available.

I believe that the description of Asian flush as a genetic mutation alludes to it being genetically inherited --68.144.245.37 21:04, 20 June 2007 (UTC)

back in teh day... people used to ferment grains/fruits (sugars) to make water safe to drink (increasing alcohol contents kills off the fermenting yeast and other organisms (bacteria, parasites, other fungi)

in asia/china instead of fermenting they relied more on boiling thier water...

thats what ive read --Twobrain 16:40, 26 July 2007 (UTC)

[edit] Test to see if gene is present?

Is there a way of testing whether to see if this gene is present? I mean, people talk about having this reaction at certain times in their lives, and not at others, with all this talk nowadays of "genetic testing" have scientists devised a way to determine whether or not this "abnormality" is present in someone? Critic9328 17:39, 22 September 2007 (UTC)

[edit] needs clarity

so is it due to either a mutation in ADH or AcetaldehydeDH? If so, these two explanations shoudl be separated better for clarity —Preceding unsigned comment added by Findingdan (talk • contribs) 20:47, 9 December 2007 (UTC)

[edit] So that explains why people turn red when they're drunk in anime then

[edit] Why citation needed on Pepcid AC

It's anecodotal by nature, why is a citation needed? I agree that we shouldn't let "anecdotal evidence suggests.." run awry, but in this case it's certianly warranted. As a college student living with people of East Asian descent, I can support the fact that there is ample anecdotal evidence to support the claim. Is it likely that there is (will ever be?) a formal study thereof? —Preceding unsigned comment added by Mpeg4codec (talk • contribs) 05:19, 23 March 2008 (UTC)