Albendazole monooxygenase

From Wikipedia, the free encyclopedia

In enzymology, an albendazole monooxygenase (EC 1.14.13.32) is an enzyme that catalyzes the chemical reaction

albendazole + NADPH + H⁺ + O₂ albendazole S-oxide + NADP⁺ + H₂O

The 4 substrates of this enzyme are albendazole, NADPH, H⁺, and O₂, whereas its 3 products are albendazole S-oxide, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is albendazole,NADPH:oxygen oxidoreductase (sulfoxide-forming). Other names in common use include albendazole oxidase, and albendazole sulfoxidase. It employs one cofactor, FAD.

[edit] References

• IUBMB entry for 1.14.13.32
• BRENDA references for 1.14.13.32 (Recommended.)
• PubMed references for 1.14.13.32
• PubMed Central references for 1.14.13.32
• Google Scholar references for 1.14.13.32
• Fargetton X, Galtier P, Delatour P (1986). "Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes". Vet. Res. Commun. 10: 317–24. doi:10.1007/BF02213995. PMID 3739217. 

[edit] External links

The CAS registry number for this enzyme class is 101299-59-6.

• IUBMB entry for 1.14.13.32

• KEGG entry for 1.14.13.32

• BRENDA entry for 1.14.13.32

• NiceZyme view of 1.14.13.32

• EC2PDB: PDB structures for 1.14.13.32

• PRIAM entry for 1.14.13.32

• PUMA2 entry for 1.14.13.32

• IntEnz: Integrated Enzyme entry for 1.14.13.32

• MetaCyc entry for 1.14.13.32

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047638: albendazole monooxygenase

• AMIGO entry for GO code 0047638: albendazole monooxygenase