AKR7A2

From Wikipedia, the free encyclopedia

Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)

PDB rendering based on 2bp1.

Available structures: 2bp1

Identifiers

Symbol(s)

AKR7A2; AFAR; AFAR1; AFB1-AR1; AKR7

External IDs

OMIM: 603418 MGI: 107796 HomoloGene: 2737

Gene ontology
Molecular Function:	• aldehyde reductase activity • electron carrier activity
Biological Process:	• carbohydrate metabolic process • aldehyde metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003689 (mRNA)
NP_003680 (protein)

NM_025337 (mRNA)
NP_079613 (protein)

Location

Chr 1: 19.5 - 19.51 Mb

Chr 4: 138.58 - 138.59 Mb

Pubmed search

[1]

[2]

Aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase), also known as AKR7A2, is a human gene.^[1]

Aldo-keto reductases, such as AKR7A2, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase).

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Ireland LS, Harrison DJ, Neal GE, Hayes JD (1998). "Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.". Biochem. J. 332 ( Pt 1): 21–34. PMID 9576847.
Praml C, Savelyeva L, Perri P, Schwab M (1998). "Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells.". Cancer Res. 58 (22): 5014–8. PMID 9823300.
Kelly VP, Sherratt PJ, Crouch DH, Hayes JD (2002). "Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins.". Biochem. J. 366 (Pt 3): 847–61. doi:10.1042/BJ20020342. PMID 12071861.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Praml C, Savelyeva L, Schwab M (2003). "Aflatoxin B1 aldehyde reductase (AFAR) genes cluster at 1p35-1p36.1 in a region frequently altered in human tumour cells.". Oncogene 22 (30): 4765–73. doi:10.1038/sj.onc.1206684. PMID 12879023.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Jordanova A, Irobi J, Thomas FP, et al. (2006). "Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.". Nat. Genet. 38 (2): 197–202. doi:10.1038/ng1727. PMID 16429158.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lyon RC, Johnston SM, Watson DG, et al. (2007). "Synthesis and catabolism of gamma-hydroxybutyrate in SH-SY5Y human neuroblastoma cells: role of the aldo-keto reductase AKR7A2.". J. Biol. Chem. 282 (36): 25986–92. doi:10.1074/jbc.M702465200. PMID 17591773.