AK2

From Wikipedia, the free encyclopedia

Adenylate kinase 2

PDB rendering based on 1ak2.

Available structures: 1ak2, 2ak2, 2c9y

Identifiers

Symbol(s)

AK2; ADK2

External IDs

OMIM: 103020 MGI: 87978 HomoloGene: 1227

Gene ontology
Molecular Function:	• nucleotide binding • adenylate kinase activity • ATP binding • kinase activity • transferase activity • nucleoside kinase activity
Cellular Component:	• mitochondrion • mitochondrial inner membrane
Biological Process:	• nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001625 (mRNA)
NP_001616 (protein)

XM_988432 (mRNA)
XP_993526 (protein)

Location

Chr 1: 33.25 - 33.28 Mb

Chr 4: 128.5 - 128.51 Mb

Pubmed search

[1]

[2]

Adenylate kinase 2, also known as AK2, is a human gene.^[1]

Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Two transcript variants encoding distinct isoforms have been identified for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: AK2 adenylate kinase 2.

[edit] Further reading

Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.". J. Steroid Biochem. Mol. Biol. 94 (1-3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Köhler C, Gahm A, Noma T, et al. (1999). "Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis.". FEBS Lett. 447 (1): 10–2. PMID 10218571.
Lee Y, Kim JW, Lee SM, et al. (1998). "Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues.". J. Biochem. 123 (1): 47–54. PMID 9504408.
Noma T, Song S, Yoon YS, et al. (1998). "cDNA cloning and tissue-specific expression of the gene encoding human adenylate kinase isozyme 2.". Biochim. Biophys. Acta 1395 (1): 34–9. PMID 9434148.
Lee Y, Kim JW, Lee IA, et al. (1997). "Cloning and characterization of cDNA for human adenylate kinase 2A.". Biochem. Mol. Biol. Int. 39 (4): 833–42. PMID 8843353.
Carritt B, King J, Welch HM (1983). "Gene order and localization of enzyme loci on the short arm of chromosome 1.". Ann. Hum. Genet. 46 (Pt 4): 329–35. PMID 6961883.
Hamada M, Sumida M, Okuda H, et al. (1982). "Adenosine triphosphate-adenosine-5'-monophosphate phosphotransferase from normal human liver mitochondria. Isolation, chemical properties, and immunochemical comparison with Duchenne dystrophic serum aberrant adenylate kinase.". J. Biol. Chem. 257 (21): 13120–8. PMID 6182143.
Bruns GA, Regina VM (1977). "Adenylate kinase 2, a mitochondrial enzyme.". Biochem. Genet. 15 (5-6): 477–86. PMID 195572.