AIFM2

From Wikipedia, the free encyclopedia

Apoptosis-inducing factor, mitochondrion-associated, 2

Identifiers

AIFM2; PRG3; AMID; RP11-367H5.2

External IDs

OMIM: 605159 MGI: 1918611 HomoloGene: 6862

Gene ontology
Molecular Function:	• DNA binding • electron-transferring-flavoprotein dehydrogenase activity • disulfide oxidoreductase activity • FAD binding
Cellular Component:	• cytoplasm • mitochondrion • mitochondrial outer membrane • cytosol • membrane • integral to membrane • outer membrane
Biological Process:	• electron transport • apoptosis • induction of apoptosis • metabolic process • apoptotic mitochondrial changes • chromosome condensation

Orthologs

Human

Mouse

Refseq

NM_032797 (mRNA)
NP_116186 (protein)

NM_001039194 (mRNA)
NP_001034283 (protein)

Location

Chr 10: 71.53 - 71.56 Mb

Chr 10: 61.11 - 61.13 Mb

Pubmed search

[1]

[2]

Apoptosis-inducing factor, mitochondrion-associated, 2, also known as AIFM2, is a human gene.^[1]

The protein encoded by this gene has significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF. Overexpression of this gene has been shown to induce apoptosis. The expression of this gene is found to be induced by tumor suppressor protein p53 in colon caner cells.^[1]

[edit] References

^ ^a ^b Entrez Gene: AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2.

[edit] Further reading

Horikoshi N, Cong J, Kley N, Shenk T (1999). "Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene.". Biochem. Biophys. Res. Commun. 261 (3): 864–9. doi:10.1006/bbrc.1999.1123. PMID 10441517.
Wu M, Xu LG, Li X, et al. (2002). "AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis.". J. Biol. Chem. 277 (28): 25617–23. doi:10.1074/jbc.M202285200. PMID 11980907.
Ohiro Y, Garkavtsev I, Kobayashi S, et al. (2002). "A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).". FEBS Lett. 524 (1-3): 163–71. PMID 12135761.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Zhang W, Li D, Mehta JL (2004). "Role of AIF in human coronary artery endothelial cell apoptosis.". Am. J. Physiol. Heart Circ. Physiol. 286 (1): H354–8. doi:10.1152/ajpheart.00579.2003. PMID 14684364.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Wu M, Xu LG, Su T, et al. (2004). "AMID is a p53-inducible gene downregulated in tumors.". Oncogene 23 (40): 6815–9. doi:10.1038/sj.onc.1207909. PMID 15273740.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Marshall KR, Gong M, Wodke L, et al. (2005). "The human apoptosis-inducing protein AMID is an oxidoreductase with a modified flavin cofactor and DNA binding activity.". J. Biol. Chem. 280 (35): 30735–40. doi:10.1074/jbc.M414018200. PMID 15958387.
Varecha M, Amrichová J, Zimmermann M, et al. (2007). "Bioinformatic and image analyses of the cellular localization of the apoptotic proteins endonuclease G, AIF, and AMID during apoptosis in human cells.". Apoptosis 12 (7): 1155–71. doi:10.1007/s10495-007-0061-0. PMID 17347867.
Gong M, Hay S, Marshall KR, et al. (2007). "DNA binding suppresses human AIF-M2 activity and provides a connection between redox chemistry, reactive oxygen species, and apoptosis.". J. Biol. Chem. 282 (41): 30331–40. doi:10.1074/jbc.M703713200. PMID 17711848.