AG 489

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AG 489
IUPAC name N-[3-[3-[3-[4-(3-aminopropylamino) butylamino] propylamino]propyl-hydroxyamino] propyl]-2-(1H-indol-3-yl)acetamide
Other names Agatoxin 489
Identifiers
CAS number [128549-96-2]
PubChem 131007
SMILES NCCCNCCCCNCCCNCCCN(O)CCCNC(Cc1c[nH]c2ccccc12)=O
Properties
Molecular formula C26H47N7O2
Molar mass 489.69708
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

AG 489 (or agatoxin 489) is a component of the venom produced by Agelenopsis aperta.[1] It inhibits the ligand gated ion channel TRPV1 through a pore blocking mechanism.[2]

[edit] References

  1. ^ Herold EE, Yaksh TL (1992). "Anesthesia and muscle relaxation with intrathecal injections of AR636 and AG489, two acylpolyamine spider toxins, in rat". Anesthesiology 77 (3): 507–12. PMID 1519789. 
  2. ^ Kitaguchi T, Swartz KJ (2005). "An inhibitor of TRPV1 channels isolated from funnel Web spider venom". Biochemistry 44 (47): 15544–9. doi:10.1021/bi051494l. PMID 16300403. 

[edit] See also

[edit] External links

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