African swine fever virus

From Wikipedia, the free encyclopedia

African swine fever virus

Macrophage cell in early stages of infection with ASFV

Group:	Group I (dsDNA)
Family:	Asfarviridae
Genus:	Asfivirus
Species:	African swine fever virus

African swine fever virus (ASFV) is the causative agent of African swine fever. ASFV is a large double-stranded DNA virus which replicates in the cytoplasm of infected cells and is the only member of the Asfarviridae family.^[1] ASFV infects domestic pigs, warthogs and bushpigs, as well as soft ticks. The virus causes a lethal haemorraghic disease in domestic pigs, some isolates can cause death of animals within as little as a week after infection. In all of the other species the virus causes no obvious disease. ASFV is endemic to Sub-Saharan Africa and exists in the wild through a cycle of infection between ticks and wild pigs/bushpigs/warthogs. ASFV was first described after European settlers brought pigs into areas endemic with ASFV and as such is an example of an 'emerging infection'.

Reddening of the ears is a common sign of African swine fever in pigs.

The clinical symptoms of ASFV are very similar to classical swine fever virus and the two diseases normally have to be distinguished by laboratory diagnosis.

African swine fever was restricted to the continent that bears its name until 1957 when the disease was reported in Lisbon, Portugal. A further outbreak occurred here in 1960. Subsequent to these initial introductions the disease became established in the Iberian peninsula and sporadic outbreaks occurred in France, Belgium and other European countries during the 1980s. Both Spain and Portugal had managed to eradicate the disease by the mid 1990s through a slaughter policy. During the late 1970s ASFV crossed the Atlantic Ocean and outbreaks were reported in some Caribbean islands, including Cuba and the Dominican Republic. Major outbreaks of ASFV in Africa are regularly reported to the l'office international des épizooties (OIE). The most recent outbreak of ASFV outside of Africa was in Georgia (country) in April 2007.

The swelling around the kidneys and the muscle hemorrhages shown here are typical of pigs with African swine fever

The appearance of ASF in the Western hemisphere at the same time as the emergence of AIDS led to some interest in whether the two were related and a report appeared in the Lancet supporting this in 1986. However, AIDS is now known to be caused by human immunodeficiency virus (HIV), no link between ASFV and AIDS has been proven or is suspected.

1 Virus structure and replication
2 See also
3 References
4 External links

[edit] Virus structure and replication

ASFV is a large double-stranded DNA virus with a genome containing at least 150 genes. The number of genes differs slightly between different isolates of the virus. ASFV has similarities to the other large DNA viruses e.g., poxvirus, iridovirus, mimivirus. In common with other viral haemorrhagic fevers, the main target cells for replication are those of monocyte, macrophage lineage. The virus causes a haemorrhagic fever with high mortality rates in pigs, but persistently infects its natural hosts, warthogs, bushpigs and soft ticks of the Ornithodoros species with no disease signs. The virus encodes enzymes required for replication and transcription of the genome, including elements of a base excision repair system, structural proteins and many proteins that are not essential for replication in cells but have roles in virus survival and transmission in its hosts. Virus replication takes place in perinuclear factory areas. Assembly of the icosahedral capsid occurs on modified membranes from the endoplasmic reticulum. Products from proteolytically processed polyproteins form the core shell between the internal membrane and the nucleoprotein core. An additional outer membrane is gained as particles bud from the plasma membrane. The virus encodes proteins that inhibit signalling pathways in infected macrophages and thus modulate transcriptional activation of immune response genes. In addition the virus encodes proteins which inhibit apoptosis of infected cells to facilitate production of progeny virions. Viral membrane proteins with similarity to cellular adhesion proteins modulate interaction of virus-infected cells and extracellular virions with host components.^[1]