ADRM1

From Wikipedia, the free encyclopedia

Adhesion regulating molecule 1

Identifiers

ADRM1; GP110; MGC29536; Rpn13

External IDs

OMIM: 610650 MGI: 1929289 HomoloGene: 10513

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane fraction • integral to plasma membrane
Biological Process:	• cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007002 (mRNA)
NP_008933 (protein)

NM_019822 (mRNA)
NP_062796 (protein)

Location

Chr 20: 60.31 - 60.32 Mb

Chr 2: 180.1 - 180.11 Mb

Pubmed search

[1]

[2]

Adhesion regulating molecule 1, also known as ADRM1, is a human gene.^[1]

The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. The encoded protein is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ADRM1 adhesion regulating molecule 1.

[edit] Further reading

Shimada S, Ogawa M, Takahashi M, et al. (1994). "Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon.". Cancer Res. 54 (14): 3831-6. PMID 8033103.
Simins AB, Weighardt H, Weidner KM, et al. (2000). "Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells.". Clin. Exp. Metastasis 17 (8): 641-8. PMID 10919708.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Kim JH, Lane WS, Reinberg D (2002). "Human Elongator facilitates RNA polymerase II transcription through chromatin.". Proc. Natl. Acad. Sci. U.S.A. 99 (3): 1241-6. doi:10.1073/pnas.251672198. PMID 11818576.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lamerant N, Kieda C (2005). "Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells.". FEBS J. 272 (8): 1833-44. doi:10.1111/j.1742-4658.2005.04613.x. PMID 15819879.
Gandhi TK, Zhong J, Mathivanan S, et al. (2006). "Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets.". Nat. Genet. 38 (3): 285-93. doi:10.1038/ng1747. PMID 16501559.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801-14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Jørgensen JP, Lauridsen AM, Kristensen P, et al. (2006). "Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor.". J. Mol. Biol. 360 (5): 1043-52. doi:10.1016/j.jmb.2006.06.011. PMID 16815440.
Yao T, Song L, Xu W, et al. (2006). "Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1.". Nat. Cell Biol. 8 (9): 994-1002. doi:10.1038/ncb1460. PMID 16906146.
Hamazaki J, Iemura S, Natsume T, et al. (2006). "A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.". EMBO J. 25 (19): 4524-36. doi:10.1038/sj.emboj.7601338. PMID 16990800.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Qiu XB, Ouyang SY, Li CJ, et al. (2007). "hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.". EMBO J. 25 (24): 5742-53. doi:10.1038/sj.emboj.7601450. PMID 17139257.