ADP-sugar diphosphatase

From Wikipedia, the free encyclopedia

In enzymology, an ADP-sugar diphosphatase (EC 3.6.1.21) is an enzyme that catalyzes the chemical reaction

ADP-sugar + H₂O AMP + alpha-D-aldose 1-phosphate

Thus, the two substrates of this enzyme are ADP-sugar and H₂O, whereas its two products are AMP and alpha-D-aldose 1-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is ADP-sugar sugarphosphohydrolase. Other names in common use include ADP-sugar pyrophosphatase, and adenosine diphosphosugar pyrophosphatase. This enzyme participates in 3 metabolic pathways: fructose and mannose metabolism, purine metabolism, and starch and sucrose metabolism.

[edit] References

• IUBMB entry for 3.6.1.21
• BRENDA references for 3.6.1.21 (Recommended.)
• PubMed references for 3.6.1.21
• PubMed Central references for 3.6.1.21
• Google Scholar references for 3.6.1.21
• Rodriguez P, Bass ST, Hansen RG (1968). "A pyrophosphatase from mammalian tissues specific for derivatives of ADP". Biochim. Biophys. Acta. 167: 199–201. PMID 5686292. 

[edit] External links

The CAS registry number for this enzyme class is 37289-32-0.

• IUBMB entry for 3.6.1.21

• KEGG entry for 3.6.1.21

• BRENDA entry for 3.6.1.21

• NiceZyme view of 3.6.1.21

• EC2PDB: PDB structures for 3.6.1.21

• PRIAM entry for 3.6.1.21

• PUMA2 entry for 3.6.1.21

• IntEnz: Integrated Enzyme entry for 3.6.1.21

• MetaCyc entry for 3.6.1.21

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0019144: ADP-sugar diphosphatase

• AMIGO entry for GO code 0019144: ADP-sugar diphosphatase