ADP-specific phosphofructokinase

From Wikipedia, the free encyclopedia

In enzymology, an ADP-specific phosphofructokinase (EC 2.7.1.146) is an enzyme that catalyzes the chemical reaction

ADP + D-fructose 6-phosphate AMP + D-fructose 1,6-bisphosphate

Thus, the two substrates of this enzyme are ADP and D-fructose 6-phosphate, whereas its two products are AMP and D-fructose 1,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ADP:D-fructose-6-phosphate 1-phosphotransferase. This enzyme is also called ADP-6-phosphofructokinase, ADP-dependent phosphofructokinase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U2X.

[edit] References

• IUBMB entry for 2.7.1.146
• BRENDA references for 2.7.1.146 (Recommended.)
• PubMed references for 2.7.1.146
• PubMed Central references for 2.7.1.146
• Google Scholar references for 2.7.1.146
• WM (1999). "Molecular and biochemical characterization of the ADP-dependent phosphofructokinase from the hyperthermophilic archaeon Pyrococcus furiosus". J. Biol. Chem. 274: 21023–8. PMID 10409652. 

[edit] External links

The CAS registry number for this enzyme class is 237739-62-7.

• IUBMB entry for 2.7.1.146

• KEGG entry for 2.7.1.146

• BRENDA entry for 2.7.1.146

• NiceZyme view of 2.7.1.146

• EC2PDB: PDB structures for 2.7.1.146

• PRIAM entry for 2.7.1.146

• PUMA2 entry for 2.7.1.146

• IntEnz: Integrated Enzyme entry for 2.7.1.146

• MetaCyc entry for 2.7.1.146

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043844: ADP-specific phosphofructokinase

• AMIGO entry for GO code 0043844: ADP-specific phosphofructokinase