ADP-specific glucokinase

From Wikipedia, the free encyclopedia

In enzymology, an ADP-specific glucokinase (EC 2.7.1.147) is an enzyme that catalyzes the chemical reaction

ADP + D-glucose AMP + D-glucose 6-phosphate

Thus, the two substrates of this enzyme are ADP and D-glucose, whereas its two products are AMP and D-glucose 6-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ADP:D-glucose 6-phosphotransferase. This enzyme is also called ADP-dependent glucokinase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1GC5.

[edit] References

• IUBMB entry for 2.7.1.147
• BRENDA references for 2.7.1.147 (Recommended.)
• PubMed references for 2.7.1.147
• PubMed Central references for 2.7.1.147
• Google Scholar references for 2.7.1.147
• Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM (1995). "Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus". J. Biol. Chem. 270: 30453–7. PMID 8530474. 

[edit] External links

• IUBMB entry for 2.7.1.147

• KEGG entry for 2.7.1.147

• BRENDA entry for 2.7.1.147

• NiceZyme view of 2.7.1.147

• EC2PDB: PDB structures for 2.7.1.147

• PRIAM entry for 2.7.1.147

• PUMA2 entry for 2.7.1.147

• IntEnz: Integrated Enzyme entry for 2.7.1.147

• MetaCyc entry for 2.7.1.147

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043843: ADP-specific glucokinase

• AMIGO entry for GO code 0043843: ADP-specific glucokinase