ADP-dependent short-chain-acyl-CoA hydrolase

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In enzymology, an ADP-dependent short-chain-acyl-CoA hydrolase (EC 3.1.2.18) is an enzyme that catalyzes the chemical reaction

acyl-CoA + H₂O $\rightleftharpoons$ CoA + a carboxylate

Thus, the two substrates of this enzyme are acyl-CoA and H₂O, whereas its two products are CoA and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is ADP-dependent-short-chain-acyl-CoA hydrolase. Other names in common use include short-chain acyl coenzyme A hydrolase, propionyl coenzyme A hydrolase, propionyl-CoA hydrolase, propionyl-CoA thioesterase, short-chain acyl-CoA hydrolase, and short-chain acyl-CoA thioesterase. It employs one cofactor, ADP. At least one compound, NADH is known to inhibit this enzyme.

[edit] References

IUBMB entry for 3.1.2.18
BRENDA references for 3.1.2.18 (Recommended.)
PubMed references for 3.1.2.18
PubMed Central references for 3.1.2.18
Google Scholar references for 3.1.2.18
Alexson SE, Nedergaard J (1988). "A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria". J. Biol. Chem. 263: 13564–71. PMID 2901416.
Alexson SE, Svensson LT, Nedergaard J (1989). "NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat". Biochim. Biophys. Acta. 1005: 13–9. PMID 2570608.