ADK (gene)

From Wikipedia, the free encyclopedia

Adenosine kinase

PDB rendering based on 1bx4.

Available structures: 1bx4, 2i6a, 2i6b

Identifiers

Symbol(s)

ADK; AK

External IDs

OMIM: 102750 MGI: 87930 HomoloGene: 4891

Gene ontology
Molecular Function:	• magnesium ion binding • adenosine kinase activity • kinase activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• purine ribonucleoside salvage • ribonucleoside monophosphate biosynthetic process

Orthologs

Human

Mouse

Refseq

NM_001123 (mRNA)
NP_001114 (protein)

NM_134079 (mRNA)
NP_598840 (protein)

Location

Chr 10: 75.58 - 76.14 Mb

Chr 14: 19.84 - 20.24 Mb

Pubmed search

[1]

[2]

Adenosine kinase, also known as ADK, is a human gene.^[1]

This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.^[1]

[edit] References

^ ^a ^b Entrez Gene: ADK adenosine kinase.

[edit] Further reading

Klobutcher LA, Nichols EA, Kucherlapati RS, Ruddle FH (1976). "Assignment of the gene for human adenosine kinase to chromosome 10 using a somatic cell hybrid clone panel.". Cytogenet. Cell Genet. 16 (1-5): 171-4. PMID 185014.
Spychala J, Datta NS, Takabayashi K, et al. (1996). "Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases.". Proc. Natl. Acad. Sci. U.S.A. 93 (3): 1232-7. PMID 8577746.
Singh B, Hao W, Wu Z, et al. (1997). "Cloning and characterization of cDNA for adenosine kinase from mammalian (Chinese hamster, mouse, human and rat) species. High frequency mutants of Chinese hamster ovary cells involve structural alterations in the gene.". Eur. J. Biochem. 241 (2): 564-71. PMID 8917457.
McNally T, Helfrich RJ, Cowart M, et al. (1997). "Cloning and expression of the adenosine kinase gene from rat and human tissues.". Biochem. Biophys. Res. Commun. 231 (3): 645-50. doi:10.1006/bbrc.1997.6157. PMID 9070863.
Mathews II, Erion MD, Ealick SE (1998). "Structure of human adenosine kinase at 1.5 A resolution.". Biochemistry 37 (45): 15607-20. doi:10.1021/bi9815445. PMID 9843365.
Van Rompay AR, Johansson M, Karlsson A (1999). "Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein.". Eur. J. Biochem. 261 (2): 509-17. PMID 10215863.
Singh B, Lin A, Wu ZC, Gupta RS (2001). "Gene structure for adenosine kinase in Chinese hamster and human: high-frequency mutants of CHO cells involve deletions of several introns and exons.". DNA Cell Biol. 20 (1): 53-65. doi:10.1089/10445490150504693. PMID 11242543.
Maguire PB, Wynne KJ, Harney DF, et al. (2003). "Identification of the phosphotyrosine proteome from thrombin activated platelets.". Proteomics 2 (6): 642-8. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells.". J. Membr. Biol. 192 (3): 169-79. PMID 12820662.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.