Talk:Adjuvant

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[edit] RFC: Vaccine template on this article and elsewhere

User:Ombudsman wishes the vacine template to be applied to this article. I think this is neither needed nor useful.

To take the process to extremes, we could end up with glass - used for the ampoule - being templated as a vaccine article because vaccines may be put up in glass ampoules. Sealed with rubber, diluted with water or saline as the usual diluent before being drawn up with a needle into a syringe.

There is no special reason to leave out any of those if "adjuvant" is templated so.

Contrariwise, each and any of these words may be linked to by square bracketting it, and this does not contribute to making WP a book where everythign is about vaccines. Midgley 13:42, 16 April 2006 (UTC)

[edit] Caffeine/Paracetamol

The article presently states:

For instance, caffeine has minimal analgesic effect on its own, but may have an adjuvant effect when given with paracetamol.

My understanding, which may very well be incorrect, was that caffeine was given with paracetamol because a common source of pain in Western societies is caffeine withdrawal. If this is a true adjuvant, and some synergy is happening here, that I am unaware of, can this be cited? Thanks Brianski 06:27, 4 August 2006 (UTC)

Yes, it can be cited in several scientific articles, e.g. Neuropharmacology 2000 Aug 23;39(11):2205-13 While adjuvant processes are often not properly understood and hard to calculate in any precise matter, due to the complexity of interacting variables, these effects have often been overlooked - hence rather nonsensical warnings that this and that medicine might interact in unexpected ways, consult your physician. This is often the case with natural remedies, like st.johns wort. I am however, befuddled as to the difference between adjuvant effects and catalysts.

[edit] Adverse effects of adjuvants

The article has the following sentence in the section on immunology:

Aluminum salts are used in some human vaccines [1], although a recent study [2] revealed aluminum adjuvants can cause neuron death.

However, the reference for the recent study links to a web article which cites unpublished data. Furthermore, the article suggests that the study did not look solely at adjuvants, but rather anthrax immunization. Thus, it is unclear that the study would at all support the conclusion that aluminum adjuvants cause neuron death. I recommend removal of this sentence until the experimental results have been published and can be evaluated. 128.95.11.93 23:48, 23 January 2007 (UTC)David J. Phippard