ADIPOR1

From Wikipedia, the free encyclopedia

Adiponectin receptor 1

Identifiers

ADIPOR1; ACDCR1; CGI-45; CGI45; FLJ25385; FLJ42464; PAQR1; TESBP1A

External IDs

OMIM: 607945 MGI: 1919924 HomoloGene: 69199

Gene ontology
Molecular Function:	• receptor activity • hormone binding • identical protein binding • protein heterodimerization activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• lipid metabolic process • hormone-mediated signaling • fatty acid oxidation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015999 (mRNA)
NP_057083 (protein)

NM_028320 (mRNA)
NP_082596 (protein)

Location

Chr 1: 201.18 - 201.19 Mb

Chr 1: 136.23 - 136.25 Mb

Pubmed search

[1]

[2]

Adiponectin receptor 1, also known as ADIPOR1, is a human gene.

The adiponectin receptors, ADIPOR1 and ADIPOR2 (MIM 607946), serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin (Yamauchi et al., 2003).[supplied by OMIM]^[1]

[edit] References

^ Entrez Gene: ADIPOR1 adiponectin receptor 1.

[edit] Further reading

Crimmins NA, Martin LJ (2007). "Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance.". Obesity reviews : an official journal of the International Association for the Study of Obesity 8 (5): 419-23. doi:10.1111/j.1467-789X.2007.00348.x. PMID 17716299.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics.". Genome Res. 10 (5): 703-13. PMID 10810093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Yamauchi T, Kamon J, Ito Y, et al. (2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.". Nature 423 (6941): 762-9. doi:10.1038/nature01705. PMID 12802337.
Kharroubi I, Rasschaert J, Eizirik DL, Cnop M (2004). "Expression of adiponectin receptors in pancreatic beta cells.". Biochem. Biophys. Res. Commun. 312 (4): 1118-22. PMID 14651988.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Civitarese AE, Jenkinson CP, Richardson D, et al. (2005). "Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes.". Diabetologia 47 (5): 816-20. doi:10.1007/s00125-004-1359-x. PMID 15105989.
Wang H, Zhang H, Jia Y, et al. (2004). "Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance.". Diabetes 53 (8): 2132-6. PMID 15277397.
Staiger H, Kaltenbach S, Staiger K, et al. (2004). "Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism.". Diabetes 53 (9): 2195-201. PMID 15331527.
Berner HS, Lyngstadaas SP, Spahr A, et al. (2005). "Adiponectin and its receptors are expressed in bone-forming cells.". Bone 35 (4): 842-9. doi:10.1016/j.bone.2004.06.008. PMID 15454091.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Punyadeera C, Zorenc AH, Koopman R, et al. (2005). "The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.". Eur. J. Endocrinol. 152 (3): 427-36. doi:10.1530/eje.1.01872. PMID 15757860.
Hara K, Horikoshi M, Kitazato H, et al. (2005). "Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes.". Diabetologia 48 (7): 1307-14. doi:10.1007/s00125-005-1806-3. PMID 15918014.
Damcott CM, Ott SH, Pollin TI, et al. (2005). "Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish.". Diabetes 54 (7): 2245-50. PMID 15983228.
Neumeier M, Weigert J, Schäffler A, et al. (2006). "Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors.". Biochem. Biophys. Res. Commun. 334 (3): 924-9. doi:10.1016/j.bbrc.2005.06.187. PMID 16023994.
Zhang J, Holt H, Wang C, et al. (2005). "Expression of AdipoR1 in vivo in skeletal muscle is independently associated with measures of truncal obesity in middle-aged caucasian men.". Diabetes Care 28 (8): 2058-60. PMID 16043761.
Tang YT, Hu T, Arterburn M, et al. (2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif.". J. Mol. Evol. 61 (3): 372-80. doi:10.1007/s00239-004-0375-2. PMID 16044242.
Jonsson JR, Moschen AR, Hickman IJ, et al. (2006). "Adiponectin and its receptors in patients with chronic hepatitis C.". J. Hepatol. 43 (6): 929-36. doi:10.1016/j.jhep.2005.05.030. PMID 16139921.