Adenosylmethionine cyclotransferase

From Wikipedia, the free encyclopedia

In enzymology, an adenosylmethionine cyclotransferase (EC 2.5.1.4) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine 5'-methylthioadenosine + 2-aminobutan-4-olide

Hence, this enzyme has one substrate, S-adenosyl-L-methionine, and two products, 5'-methylthioadenosine and 2-aminobutan-4-olide.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is S-adenosyl-L-methionine alkyltransferase (cyclizing). This enzyme is also called adenosylmethioninase.

[edit] References

• IUBMB entry for 2.5.1.4
• BRENDA references for 2.5.1.4 (Recommended.)
• PubMed references for 2.5.1.4
• PubMed Central references for 2.5.1.4
• Google Scholar references for 2.5.1.4
• Mudd SH (1959). "Enzymatic cleavage of S-adenosylmethionine". J. Biol. Chem. 234: 87–92. 
• Mudd SH (1959). "The mechanism of the enzymatic cleavage of S-adenosylmethionine to alpha-amino-gamma-butyrolactone". J. Biol. Chem. 234: 1784–1786. 

[edit] External links

The CAS registry number for this enzyme class is 9030-34-6.

• IUBMB entry for 2.5.1.4

• KEGG entry for 2.5.1.4

• BRENDA entry for 2.5.1.4

• NiceZyme view of 2.5.1.4

• EC2PDB: PDB structures for 2.5.1.4

• PRIAM entry for 2.5.1.4

• PUMA2 entry for 2.5.1.4

• IntEnz: Integrated Enzyme entry for 2.5.1.4

• MetaCyc entry for 2.5.1.4

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047625: adenosylmethionine cyclotransferase

• AMIGO entry for GO code 0047625: adenosylmethionine cyclotransferase