Adenosylcobinamide hydrolase

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In enzymology, an adenosylcobinamide hydrolase (EC 3.5.1.90) is an enzyme that catalyzes the chemical reaction

adenosylcobinamide + H₂O adenosylcobyric acid + (R)-1-aminopropan-2-ol

Thus, the two substrates of this enzyme are adenosylcobinamide and H₂O, whereas its two products are adenosylcobyric acid and (R)-1-aminopropan-2-ol.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is adenosylcobinamide amidohydrolase. Other names in common use include CbiZ, and AdoCbi amidohydrolase. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

• IUBMB entry for 3.5.1.90
• BRENDA references for 3.5.1.90 (Recommended.)
• PubMed references for 3.5.1.90
• PubMed Central references for 3.5.1.90
• Google Scholar references for 3.5.1.90
• Woodson JD, Escalante-Semerena JC (2004). "CbiZ, an amidohydrolase enzyme required for salvaging the coenzyme B12 precursor cobinamide in archaea". Proc. Natl. Acad. Sci. U. S. A. 101: 3591–6. PMID 14990804. 

[edit] External links

The CAS registry number for this enzyme class is 905988-16-1.

• IUBMB entry for 3.5.1.90

• KEGG entry for 3.5.1.90

• BRENDA entry for 3.5.1.90

• NiceZyme view of 3.5.1.90

• EC2PDB: PDB structures for 3.5.1.90

• PRIAM entry for 3.5.1.90

• PUMA2 entry for 3.5.1.90

• IntEnz: Integrated Enzyme entry for 3.5.1.90

• MetaCyc entry for 3.5.1.90

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0043756: adenosylcobinamide hydrolase

• AMIGO entry for GO code 0043756: adenosylcobinamide hydrolase