Adenosylcobinamide-phosphate guanylyltransferase

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In enzymology, an adenosylcobinamide-phosphate guanylyltransferase (EC 2.7.7.62) is an enzyme that catalyzes the chemical reaction

GTP + adenosylcobinamide phosphate $\rightleftharpoons$ diphosphate + adenosylcobinamide-GDP

Thus, the two substrates of this enzyme are GTP and adenosylcobinamide phosphate, whereas its two products are diphosphate and adenosylcobinamide-GDP.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:adenosylcobinamide-phosphate guanylyltransferase. Other names in common use include CobU, adenosylcobinamide kinase/adenosylcobinamide-phosphate, guanylyltransferase, and AdoCbi kinase/AdoCbi-phosphate guanylyltransferase. This enzyme participates in porphyrin and chlorophyll metabolism.

[edit] References

IUBMB entry for 2.7.7.62
BRENDA references for 2.7.7.62 (Recommended.)
PubMed references for 2.7.7.62
PubMed Central references for 2.7.7.62
Google Scholar references for 2.7.7.62
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Thompson TB, Thomas MG, Escalante-Semerena JC, Rayment I (1998). "Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase from Salmonella typhimurium determined to 2.3 A resolution,". Biochemistry. 37: 7686–95. doi:10.1021/bi973178f. PMID 9601028.
Thompson TB, Thomas MG, Escalante-Semerena JC, Rayment I (1999). "Three-dimensional structure of adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase (CobU) complexed with GMP: evidence for a substrate-induced transferase active site". Biochemistry. 38: 12995–3005. doi:10.1021/bi990910x. PMID 10529169.
Thomas MG, Thompson TB, Rayment I, Escalante-Semerena JC (2000). "Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation". J. Biol. Chem. 275: 27576–86. PMID 10869342.
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC (2002). "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19: 390–412. doi:10.1039/b108967f. PMID 12195810.