Adenosine-tetraphosphatase

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In enzymology, an adenosine-tetraphosphatase (EC 3.6.1.14) is an enzyme that catalyzes the chemical reaction

adenosine 5'-tetraphosphate + H₂O ATP + phosphate

Thus, the two substrates of this enzyme are adenosine 5'-tetraphosphate and H₂O, whereas its two products are ATP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is adenosine-tetraphosphate phosphohydrolase. This enzyme participates in purine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2V7Q.

[edit] References

• IUBMB entry for 3.6.1.14
• BRENDA references for 3.6.1.14 (Recommended.)
• PubMed references for 3.6.1.14
• PubMed Central references for 3.6.1.14
• Google Scholar references for 3.6.1.14
• Small GD, Cooper C (1966). "Purification and properties of nucleoside tetraphosphate hydrolase from rabbit muscle". Biochemistry. 5: 14–26. doi:10.1021/bi00865a003. PMID 4287215. 

[edit] External links

The CAS registry number for this enzyme class is 37289-26-2.

• IUBMB entry for 3.6.1.14

• KEGG entry for 3.6.1.14

• BRENDA entry for 3.6.1.14

• NiceZyme view of 3.6.1.14

• EC2PDB: PDB structures for 3.6.1.14

• PRIAM entry for 3.6.1.14

• PUMA2 entry for 3.6.1.14

• IntEnz: Integrated Enzyme entry for 3.6.1.14

• MetaCyc entry for 3.6.1.14

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047624: adenosine-tetraphosphatase

• AMIGO entry for GO code 0047624: adenosine-tetraphosphatase