Adenine deaminase

From Wikipedia, the free encyclopedia

In enzymology, an adenine deaminase (EC 3.5.4.2) is an enzyme that catalyzes the chemical reaction

adenine + H₂O hypoxanthine + NH₃

Thus, the two substrates of this enzyme are adenine and H₂O, whereas its two products are hypoxanthine and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is adenine aminohydrolase. Other names in common use include adenase, adenine aminase, and ADase. This enzyme participates in purine metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2ICS.

[edit] References

• IUBMB entry for 3.5.4.2
• BRENDA references for 3.5.4.2 (Recommended.)
• PubMed references for 3.5.4.2
• PubMed Central references for 3.5.4.2
• Google Scholar references for 3.5.4.2
• Blauch M, Koch FC and Hane ME (1939). "A study of xanthine oxidase of rat blood". J. Biol. Chem. 130: 471–486. 
• Heppel LA, Hurwitz J and Horecker BL (1957). "Adenine deaminase of Azotobacter vinelandii". J. Am. Chem. Soc. 79: 630–633. 

[edit] External links

The CAS registry number for this enzyme class is 9027-68-3.

• IUBMB entry for 3.5.4.2

• KEGG entry for 3.5.4.2

• BRENDA entry for 3.5.4.2

• NiceZyme view of 3.5.4.2

• EC2PDB: PDB structures for 3.5.4.2

• PRIAM entry for 3.5.4.2

• PUMA2 entry for 3.5.4.2

• IntEnz: Integrated Enzyme entry for 3.5.4.2

• MetaCyc entry for 3.5.4.2

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0000034: adenine deaminase

• AMIGO entry for GO code 0000034: adenine deaminase