ADCY9

From Wikipedia, the free encyclopedia

Adenylate cyclase 9

Identifiers

External IDs

OMIM: 603302 MGI: 108450 HomoloGene: 868

Gene ontology
Molecular Function:	• magnesium ion binding • adenylate cyclase activity
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• cAMP biosynthetic process • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001116 (mRNA)
NP_001107 (protein)

NM_009624 (mRNA)
NP_033754 (protein)

Location

Chr 16: 3.95 - 4.11 Mb

Chr 16: 4.2 - 4.34 Mb

Pubmed search

[1]

[2]

Adenylate cyclase 9, also known as ADCY9, is a human gene.^[1]

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.^[1]

[edit] References

^ ^a ^b Entrez Gene: ADCY9 adenylate cyclase 9.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954.
Paterson JM, Smith SM, Harmar AJ, Antoni FA (1995). "Control of a novel adenylyl cyclase by calcineurin.". Biochem. Biophys. Res. Commun. 214 (3): 1000-8. doi:10.1006/bbrc.1995.2385. PMID 7575502.
Premont RT, Matsuoka I, Mattei MG, et al. (1996). "Identification and characterization of a widely expressed form of adenylyl cyclase.". J. Biol. Chem. 271 (23): 13900-7. PMID 8662814.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31-9. PMID 9628581.
Hacker BM, Tomlinson JE, Wayman GA, et al. (1999). "Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9).". Genomics 50 (1): 97-104. doi:10.1006/geno.1998.5293. PMID 9628827.
Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538-46. PMID 10089566.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629-36. PMID 10807185.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975-82. doi:10.1067/mai.2000.105315. PMID 10808179.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399-407. PMID 11299302.
Toyota T, Hattori E, Meerabux J, et al. (2002). "Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders.". Am. J. Med. Genet. 114 (1): 84-92. PMID 11840511.
Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.". J. Virol. 76 (7): 3179-88. PMID 11884542.
Toyota T, Yamada K, Saito K, et al. (2002). "Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder.". Mol. Psychiatry 7 (5): 450-2. doi:10.1038/sj.mp.4000992. PMID 12082561.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.". J. Recept. Signal Transduct. Res. 22 (1-4): 79-110. PMID 12503609.
Small KM, Brown KM, Theiss CT, et al. (2004). "An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation.". Pharmacogenetics 13 (9): 535-41. doi:10.1097/01.fpc.0000054119.14659.01. PMID 12972952.
Cumbay MG, Watts VJ (2004). "Novel regulatory properties of human type 9 adenylate cyclase.". J. Pharmacol. Exp. Ther. 310 (1): 108-15. doi:10.1124/jpet.104.065748. PMID 14996950.
Tantisira KG, Small KM, Litonjua AA, et al. (2005). "Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways.". Hum. Mol. Genet. 14 (12): 1671-7. doi:10.1093/hmg/ddi175. PMID 15879435.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.