ADCY7

From Wikipedia, the free encyclopedia

Adenylate cyclase 7

Identifiers

ADCY7; FLJ36387; KIAA0037

External IDs

OMIM: 600385 MGI: 102891 HomoloGene: 866

Gene ontology
Molecular Function:	• magnesium ion binding • adenylate cyclase activity
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• cAMP biosynthetic process • adenylate cyclase activation • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001114 (mRNA)
NP_001105 (protein)

NM_001037723 (mRNA)
NP_001032812 (protein)

Location

Chr 16: 48.88 - 48.91 Mb

Chr 8: 91.16 - 91.22 Mb

Pubmed search

[1]

[2]

Adenylate cyclase 7, also known as ADCY7, is a human gene.^[1]

This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.^[1]

[edit] References

^ ^a ^b Entrez Gene: ADCY7 adenylate cyclase 7.

[edit] Further reading

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.". DNA Res. 1 (1): 27-35. PMID 7584026.
Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).". DNA Res. 1 (1): 47-56. PMID 7584028.
Hellevuo K, Berry R, Sikela JM, Tabakoff B (1995). "Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16.". Hum. Genet. 95 (2): 197-200. PMID 7860067.
Hellevuo K, Welborn R, Menninger JA, Tabakoff B (1997). "Human adenylyl cyclase type 7 contains polymorphic repeats in the 3' untranslated region: investigations of association with alcoholism.". Am. J. Med. Genet. 74 (1): 95-8. PMID 9034014.
Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538-46. PMID 10089566.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629-36. PMID 10807185.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975-82. doi:10.1067/mai.2000.105315. PMID 10808179.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399-407. PMID 11299302.
Yan SZ, Tang WJ (2002). "Construction of soluble adenylyl cyclase from human membrane-bound type 7 adenylyl cyclase.". Meth. Enzymol. 345: 231-41. PMID 11665607.
Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.". J. Virol. 76 (7): 3179-88. PMID 11884542.
Nelson EJ, Hellevuo K, Yoshimura M, Tabakoff B (2003). "Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta.". J. Biol. Chem. 278 (7): 4552-60. doi:10.1074/jbc.M210386200. PMID 12454008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.". J. Recept. Signal Transduct. Res. 22 (1-4): 79-110. PMID 12503609.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Beeler JA, Yan SZ, Bykov S, et al. (2005). "A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase.". Biochemistry 43 (49): 15463-71. doi:10.1021/bi049088+. PMID 15581358.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Hines LM, Hoffman PL, Bhave S, et al. (2006). "A sex-specific role of type VII adenylyl cyclase in depression.". J. Neurosci. 26 (48): 12609-19. doi:10.1523/JNEUROSCI.1040-06.2006. PMID 17135423.