ADCY5

From Wikipedia, the free encyclopedia

Adenylate cyclase 5

PDB rendering based on 1azs.

Available structures: 1azs, 1cjk, 1cjt, 1cju, 1cjv, 1cs4, 1cul, 1tl7, 1u0h, 2gvd, 2gvz

Identifiers

Symbol(s)

ADCY5;

External IDs

OMIM: 600293 MGI: 99673 HomoloGene: 11213

Gene ontology
Molecular Function:	• magnesium ion binding • adenylate cyclase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• adenosine receptor signaling pathway • cAMP biosynthetic process • dopamine receptor, adenylate cyclase activating pathway • dopamine receptor, adenylate cyclase inhibiting pathway • intracellular signaling cascade • locomotory behavior • regulation of balance

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_183357 (mRNA)
NP_899200 (protein)

XM_916755 (mRNA)
XP_921848 (protein)

Location

Chr 3: 124.49 - 124.65 Mb

Chr 16: 35.07 - 35.22 Mb

Pubmed search

[1]

[2]

Adenylate cyclase 5, also known as ADCY5, is a human gene.^[1]

[edit] References

^ Entrez Gene: ADCY5 adenylate cyclase 5.

[edit] Further reading

Yoshimura M, Cooper DM (1992). "Cloning and expression of a Ca(2+)-inhibitable adenylyl cyclase from NCB-20 cells.". Proc. Natl. Acad. Sci. U.S.A. 89 (15): 6716–20. PMID 1379717.
Iwami G, Kawabe J, Ebina T, et al. (1995). "Regulation of adenylyl cyclase by protein kinase A.". J. Biol. Chem. 270 (21): 12481–4. PMID 7759492.
Haber N, Stengel D, Defer N, et al. (1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.". Hum. Genet. 94 (1): 69–73. PMID 8034296.
Kawabe J, Iwami G, Ebina T, et al. (1994). "Differential activation of adenylyl cyclase by protein kinase C isoenzymes.". J. Biol. Chem. 269 (24): 16554–8. PMID 8206971.
Scholich K, Barbier AJ, Mullenix JB, Patel TB (1997). "Characterization of soluble forms of nonchimeric type V adenylyl cyclases.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2915–20. PMID 9096321.
Sunahara RK, Dessauer CW, Whisnant RE, et al. (1997). "Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase.". J. Biol. Chem. 272 (35): 22265–71. PMID 9268375.
Scholich K, Wittpoth C, Barbier AJ, et al. (1997). "Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsalpha.". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9602–7. PMID 9275169.
Dessauer CW, Tesmer JJ, Sprang SR, Gilman AG (1998). "Identification of a Gialpha binding site on type V adenylyl cyclase.". J. Biol. Chem. 273 (40): 25831–9. PMID 9748257.
Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538–46. PMID 10089566.
Raimundo S, Giray J, Volff JN, et al. (1999). "Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues.". Clin. Chim. Acta 285 (1-2): 155–61. PMID 10481931.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629–36. PMID 10807185.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399–407. PMID 11299302.
Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. PMID 11549699.
Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.". J. Virol. 76 (7): 3179–88. PMID 11884542.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.". J. Recept. Signal Transduct. Res. 22 (1-4): 79–110. PMID 12503609.
Salim S, Sinnarajah S, Kehrl JH, Dessauer CW (2003). "Identification of RGS2 and type V adenylyl cyclase interaction sites.". J. Biol. Chem. 278 (18): 15842–9. doi:10.1074/jbc.M210663200. PMID 12604604.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3.". Nature 440 (7088): 1194–8. doi:10.1038/nature04728. PMID 16641997.
Bauman AL, Soughayer J, Nguyen BT, et al. (2006). "Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.". Mol. Cell 23 (6): 925–31. doi:10.1016/j.molcel.2006.07.025. PMID 16973443.