ADCY3

From Wikipedia, the free encyclopedia

Adenylate cyclase 3

Identifiers

ADCY3; AC3; KIAA0511

External IDs

OMIM: 600291 MGI: 99675 HomoloGene: 2978

Gene ontology
Molecular Function:	• magnesium ion binding • adenylate cyclase activity • calmodulin binding
Cellular Component:	• plasma membrane • integral to plasma membrane
Biological Process:	• cAMP biosynthetic process • intracellular signaling cascade • sensory perception of smell • response to stimulus

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004036 (mRNA)
NP_004027 (protein)

NM_138305 (mRNA)
NP_612178 (protein)

Location

Chr 2: 24.9 - 25 Mb

Chr 12: 4.13 - 4.21 Mb

Pubmed search

[1]

[2]

Adenylate cyclase 3, also known as ADCY3, is a human gene.^[1]

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes.^[1]

[edit] References

^ ^a ^b Entrez Gene: ADCY3 adenylate cyclase 3.

[edit] Further reading

Gaudin C, Homcy CJ, Ishikawa Y (1994). "Mammalian adenylyl cyclase family members are randomly located on different chromosomes.". Hum. Genet. 94 (5): 527–9. PMID 7959689.
Haber N, Stengel D, Defer N, et al. (1994). "Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI.". Hum. Genet. 94 (1): 69–73. PMID 8034296.
Hellevuo K, Yoshimura M, Kao M, et al. (1993). "A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line.". Biochem. Biophys. Res. Commun. 192 (1): 311–8. doi:10.1006/bbrc.1993.1415. PMID 8476432.
Wei J, Wayman G, Storm DR (1996). "Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo.". J. Biol. Chem. 271 (39): 24231–5. PMID 8798667.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581.
Wei J, Zhao AZ, Chan GC, et al. (1998). "Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals.". Neuron 21 (3): 495–504. PMID 9768837.
Yang B, He B, Abdel-Halim SM, et al. (1999). "Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets.". Biochem. Biophys. Res. Commun. 254 (3): 548–51. doi:10.1006/bbrc.1998.9983. PMID 9920776.
Barcova M, Speth C, Kacani L, et al. (1999). "Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.". Pflugers Arch. 437 (4): 538–46. PMID 10089566.
Speth C, Joebstl B, Barcova M, Dierich MP (2000). "HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.". AIDS 14 (6): 629–36. PMID 10807185.
Patke CL, Shearer WT (2000). "gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.". J. Allergy Clin. Immunol. 105 (5): 975–82. doi:10.1067/mai.2000.105315. PMID 10808179.
Vanvooren V, Allgeier A, Cosson E, et al. (2001). "Expression of multiple adenylyl cyclase isoforms in human and dog thyroid.". Mol. Cell. Endocrinol. 170 (1-2): 185–96. PMID 11162902.
Patrizio M, Colucci M, Levi G (2001). "Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.". J. Neurochem. 77 (2): 399–407. PMID 11299302.
Côté M, Guillon G, Payet MD, Gallo-Payet N (2001). "Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland.". J. Clin. Endocrinol. Metab. 86 (9): 4495–503. PMID 11549699.
Speth C, Schabetsberger T, Mohsenipour I, et al. (2002). "Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.". J. Virol. 76 (7): 3179–88. PMID 11884542.
Kobayakawa K, Hayashi R, Morita K, et al. (2002). "Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons.". J. Neurosci. 22 (14): 5931–7. PMID 12122055.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ludwig MG, Seuwen K (2003). "Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.". J. Recept. Signal Transduct. Res. 22 (1-4): 79–110. PMID 12503609.
Katsel PL, Tagliente TM, Schwarz TE, et al. (2003). "Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets.". Platelets 14 (1): 21–33. PMID 12623444.
Celano M, Arturi F, Presta I, et al. (2004). "Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules.". Mol. Cell. Endocrinol. 203 (1-2): 129–35. PMID 12782409.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.