AD-36
From Wikipedia, the free encyclopedia
| AD-36 | ||||||||
|---|---|---|---|---|---|---|---|---|
| Virus classification | ||||||||
|
Human adenovirus 36 (HAdV-36) or AD-36 is one of 51 types of adenoviruses known to infect humans. It was first shown to be associated with obesity in chickens by Dr. Nikhil Dhurandhar.[1][2]
There has been a positive correlation between body fat and the presence of AD-36 antibodies in the blood (International Journal of Obesity vol29 pages 281-286). Previous research showed that chicken or mice injected with similar types of viruses show a statistically significant weight gain.[1]
To date, AD-36 is the only human adenovirus that has been linked with human obesity, present in 30% of obese humans and 11% of nonobese humans.[3] AD-36 also causes obesity in chickens, mice, rats, and monkeys.[3]
AD-36 infection can induce cellular differentiation of 3T3-L1 preadipocytes and stem cells derived from human adipose tissue.[4]
[edit] References
- ^ a b Dhurandhar, N V; B A Israel, J M Kolesar, G F Mayhew, M E Cook, R L Atkinson (2000). "Increased adiposity in animals due to a human virus". International Journal of Obesity 24: 989-996.
- ^ Whigham, Leah D.; Barbara A. Israel, and Richard L. Atkinson (2006). "Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals". Am J Physiol Regul Integr Comp Physiol 290: R190-R194.
- ^ a b Atkinson RL (2007). "Viruses as an etiology of obesity". Mayo Clin. Proc. 82 (10): 1192–8. PMID 17908526.
- ^ Rogers PM, Fusinski KA, Rathod MA, et al (2007). "Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene". Int J Obes (Lond): 397. doi:. PMID 17984979.
