Acylphosphatase

From Wikipedia, the free encyclopedia

In enzymology, an acylphosphatase (EC 3.6.1.7) is an enzyme that catalyzes the chemical reaction

an acylphosphate + H₂O $\rightleftharpoons$ a carboxylate + phosphate

Thus, the two substrates of this enzyme are acylphosphate and H₂O, whereas its two products are carboxylate and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is acylphosphate phosphohydrolase. Other names in common use include acetylphosphatase, 1,3-diphosphoglycerate phosphatase, acetic phosphatase, Ho 1-3, and GP 1-3. This enzyme participates in 3 metabolic pathways: glycolysis / gluconeogenesis, pyruvate metabolism, and benzoate degradation via coa ligation.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1APS, 1ULR, 1URR, 1V3Z, 1W2I, 1Y9O, 2ACY, 2BJD, 2BJE, 2FHM, 2GV1, 2HLT, and 2HLU.

[edit] References

IUBMB entry for 3.6.1.7
BRENDA references for 3.6.1.7 (Recommended.)
PubMed references for 3.6.1.7
PubMed Central references for 3.6.1.7
Google Scholar references for 3.6.1.7
Raijman L, Grisolia S and Edelhoch H (1960). "Further purification and properties of brain acyl phosphatase". J. Biol. Chem. 235: 2340–2342.
Ramponi G, Guerritore A, Treves C, Nassi P, Baccari V (1969). "Horse muscle acyl phosphatase: purification and some properties". Arch. Biochem. Biophys. 130: 362–9. doi:10.1016/0003-9861(69)90045-9. PMID 4305161.
Ramponi G, Nassi P, Cappugi G, Treves C, Manao G (1972). "Purification and some molecular properties of horse liver acyl phosphatase". Biochim. Biophys. Acta. 284: 485–96. PMID 4344156.
Shiokawa H, Noda L (1970). "Isolation and crystallization of acyl phosphatase from rabbit muscle". J. Biol. Chem. 245: 669–73. PMID 4313603.