Acylglycerone-phosphate reductase

From Wikipedia, the free encyclopedia

In enzymology, an acylglycerone-phosphate reductase (EC 1.1.1.101) is an enzyme that catalyzes the chemical reaction

1-palmitoylglycerol 3-phosphate + NADP⁺ palmitoylglycerone phosphate + NADPH + H⁺

Thus, the two substrates of this enzyme are 1-palmitoylglycerol 3-phosphate and NADP⁺, whereas its 3 products are palmitoylglycerone phosphate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase. Other names in common use include palmitoyldihydroxyacetone-phosphate reductase, palmitoyl dihydroxyacetone phosphate reductase, palmitoyl-dihydroxyacetone-phosphate reductase, acyldihydroxyacetone phosphate reductase, and palmitoyl dihydroxyacetone phosphate reductase. This enzyme participates in glycerophospholipid and ether lipid metabolism.

[edit] References

• IUBMB entry for 1.1.1.101
• BRENDA references for 1.1.1.101 (Recommended.)
• PubMed references for 1.1.1.101
• PubMed Central references for 1.1.1.101
• Google Scholar references for 1.1.1.101
• LaBelle EF Jr, Hajra AK (1972). "Enzymatic reduction of alkyl and acyl derivatives of dihydroxyacetone phosphate by reduced pyridine nucleotides". J. Biol. Chem. 247: 5825–34. PMID 4403490. 

[edit] External links

The CAS registry number for this enzyme class is 37250-35-4.

• IUBMB entry for 1.1.1.101

• KEGG entry for 1.1.1.101

• BRENDA entry for 1.1.1.101

• NiceZyme view of 1.1.1.101

• EC2PDB: PDB structures for 1.1.1.101

• PRIAM entry for 1.1.1.101

• PUMA2 entry for 1.1.1.101

• IntEnz: Integrated Enzyme entry for 1.1.1.101

• MetaCyc entry for 1.1.1.101

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0000140: acylglycerone-phosphate reductase

• AMIGO entry for GO code 0000140: acylglycerone-phosphate reductase