Acylcarnitine hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an acylcarnitine hydrolase (EC 3.1.1.28) is an enzyme that catalyzes the chemical reaction

O-acylcarnitine + H₂O a fatty acid + L-carnitine

Thus, the two substrates of this enzyme are O-acylcarnitine and H₂O, whereas its two products are fatty acid and L-carnitine.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is O-acylcarnitine acylhydrolase. Other names in common use include high activity acylcarnitine hydrolase, HACH, carnitine ester hydrolase, palmitoylcarnitine hydrolase, palmitoyl-L-carnitine hydrolase, long-chain acyl-L-carnitine hydrolase, and palmitoyl carnitine hydrolase.

[edit] References

• IUBMB entry for 3.1.1.28
• BRENDA references for 3.1.1.28 (Recommended.)
• PubMed references for 3.1.1.28
• PubMed Central references for 3.1.1.28
• Google Scholar references for 3.1.1.28
• Mahadevan S, Sauer F (1969). "Carnitine ester hydrolase of rat liver". J. Biol. Chem. 244: 4448–53. PMID 5806585. 
• Mentlein R, Reuter G, Heymann E (1985). "Specificity of two different purified acylcarnitine hydrolases from rat liver, their identity with other carboxylesterases, and their possible function". Arch. Biochem. Biophys. 240: 801–10. doi:10.1016/0003-9861(85)90089-X. PMID 4026306. 

[edit] External links

The CAS registry number for this enzyme class is 37278-42-5.

• IUBMB entry for 3.1.1.28

• KEGG entry for 3.1.1.28

• BRENDA entry for 3.1.1.28

• NiceZyme view of 3.1.1.28

• EC2PDB: PDB structures for 3.1.1.28

• PRIAM entry for 3.1.1.28

• PUMA2 entry for 3.1.1.28

• IntEnz: Integrated Enzyme entry for 3.1.1.28

• MetaCyc entry for 3.1.1.28

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047619: acylcarnitine hydrolase

• AMIGO entry for GO code 0047619: acylcarnitine hydrolase