Acyl-CoA oxidase

From Wikipedia, the free encyclopedia

In enzymology, an acyl-CoA oxidase (EC 1.3.3.6) is an enzyme that catalyzes the chemical reaction

acyl-CoA + O₂ $\rightleftharpoons$ trans-2,3-dehydroacyl-CoA + H₂O₂

Thus, the two substrates of this enzyme are acyl-CoA and O₂, whereas its two products are trans-2,3-dehydroacyl-CoA and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with oxygen as acceptor. The systematic name of this enzyme class is acyl-CoA:oxygen 2-oxidoreductase. Other names in common use include fatty acyl-CoA oxidase, acyl coenzyme A oxidase, and fatty acyl-coenzyme A oxidase. This enzyme participates in 3 metabolic pathways: fatty acid metabolism, polyunsaturated fatty acid biosynthesis, and ppar signaling pathway. It employs one cofactor, FAD.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1IS2, 1W07, 2DDH, 2FON, 2IX5, and 2IX6.

[edit] References

IUBMB entry for 1.3.3.6
BRENDA references for 1.3.3.6 (Recommended.)
PubMed references for 1.3.3.6
PubMed Central references for 1.3.3.6
Google Scholar references for 1.3.3.6
T, Kikuchi T, Ando M, Okuda S (Tokyo). "Stereochemistry of dehydrogenation catalyzed by Acyl-CoA oxidase". J. Biochem.: 1481–6. PMID 7462191.
Osumi T, Hashimoto T, Ui N (Tokyo). "Purification and properties of acyl-CoA oxidase from rat liver". J. Biochem.: 1735–46. PMID 7400120.