Acyl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, an acyl-CoA hydrolase (EC 3.1.2.20) is an enzyme that catalyzes the chemical reaction

acyl-CoA + H₂O CoA + a carboxylate

Thus, the two substrates of this enzyme are acyl-CoA and H₂O, whereas its two products are CoA and carboxylate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is acyl-CoA hydrolase. Other names in common use include acyl coenzyme A thioesterase, acyl-CoA thioesterase, acyl coenzyme A hydrolase, thioesterase B, thioesterase II, and acyl-CoA thioesterase.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y7U and 2GVH.

[edit] References

• IUBMB entry for 3.1.2.20
• BRENDA references for 3.1.2.20 (Recommended.)
• PubMed references for 3.1.2.20
• PubMed Central references for 3.1.2.20
• Google Scholar references for 3.1.2.20
• Alexson SE, Svensson LT, Nedergaard J (1989). "NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat". Biochim. Biophys. Acta. 1005: 13–9. PMID 2570608. 

[edit] External links

The CAS registry number for this enzyme class is 37270-64-7.

• IUBMB entry for 3.1.2.20

• KEGG entry for 3.1.2.20

• BRENDA entry for 3.1.2.20

• NiceZyme view of 3.1.2.20

• EC2PDB: PDB structures for 3.1.2.20

• PRIAM entry for 3.1.2.20

• PUMA2 entry for 3.1.2.20

• IntEnz: Integrated Enzyme entry for 3.1.2.20

• MetaCyc entry for 3.1.2.20

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047617: acyl-CoA hydrolase

• AMIGO entry for GO code 0047617: acyl-CoA hydrolase