Acyl-(acyl-carrier-protein)-UDP-N-acetylglucosamine O-acyltransferase

From Wikipedia, the free encyclopedia

In enzymology, an acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase (EC 2.3.1.129) is an enzyme that catalyzes the chemical reaction

(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine

Thus, the two substrates of this enzyme are (R)-3-hydroxytetradecanoyl-acyl-carrier-protein and UDP-N-acetylglucosamine, whereas its two products are acyl-carrier-protein and UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is (R)-3-hydroxytetradecanoyl-[acyl-carrier-protein]:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase. Other names in common use include UDP-N-acetylglucosamine acyltransferase and uridine diphosphoacetylglucosamine acyltransferase. This enzyme participates in lipopolysaccharide biosynthesis.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1J2Z, 1LXA, 2AQ9, 2JF2, 2JF3, 2QIA, and 2QIV.

[edit] References

• IUBMB entry for 2.3.1.129
• BRENDA references for 2.3.1.129 (Recommended.)
• PubMed references for 2.3.1.129
• PubMed Central references for 2.3.1.129
• Google Scholar references for 2.3.1.129
• Anderson MS, Bulawa CE, Raetz CR (1985). "The biosynthesis of gram-negative endotoxin. Formation of lipid A precursors from UDP-GlcNAc in extracts of Escherichia coli". J. Biol. Chem. 260: 15536–41. PMID 3905795. 

[edit] External links

The CAS registry number for this enzyme class is 105843-69-4.

• IUBMB entry for 2.3.1.129

• KEGG entry for 2.3.1.129

• BRENDA entry for 2.3.1.129

• NiceZyme view of 2.3.1.129

• EC2PDB: PDB structures for 2.3.1.129

• PRIAM entry for 2.3.1.129

• PUMA2 entry for 2.3.1.129

• IntEnz: Integrated Enzyme entry for 2.3.1.129

• MetaCyc entry for 2.3.1.129

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008780: acyl-[acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase]

• AMIGO entry for GO code 0008780: acyl-[acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase]