ACYP1

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Acylphosphatase 1, erythrocyte (common) type
Identifiers
Symbol(s) ACYP1; ACYPE
External IDs OMIM: 600875 MGI: 1913454 HomoloGene: 11932
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 97 66204
Ensembl ENSG00000119640 ENSMUSG00000008822
Uniprot P07311 Q0VG40
Refseq NM_001107 (mRNA)
NP_001098 (protein)		 NM_025421 (mRNA)
NP_079697 (protein)
Location Chr 14: 74.59 - 74.6 Mb Chr 12: 86.16 - 86.17 Mb
Pubmed search [1] [2]

Acylphosphatase 1, erythrocyte (common) type, also known as ACYP1, is a human gene.[1]

Acylphosphatase is a small cytosolic enzyme that catalyzes the hydrolysis of the carboxyl-phosphate bond of acylphosphates. Two isoenzymes have been isolated, called muscle acylphosphatase and erythrocyte acylphosphatase, on the basis of their tissue localization. This gene encodes the erythrocyte acylphosphatase isoenzyme. Alternatively spliced transcript variants that encode different proteins were identified through data analysis.[1]

[edit] References

  1. ^ a b Entrez Gene: ACYP1 acylphosphatase 1, erythrocyte (common) type.

[edit] Further reading

  • Nassi P, Nediani C, Liguri G, et al. (1991). "Effects of acylphosphatase on the activity of erythrocyte membrane Ca2+ pump.". J. Biol. Chem. 266 (17): 10867–71. PMID 1645713. 
  • Degl'Innocenti D, Berti A, Stefani M, et al. (1990). "Immunoaffinity purification and immunoassay determination of human erythrocyte acylphosphatase.". Biotechnol. Appl. Biochem. 12 (4): 450–9. PMID 2169259. 
  • Liguri G, Camici G, Manao G, et al. (1987). "A new acylphosphatase isoenzyme from human erythrocytes: purification, characterization, and primary structure.". Biochemistry 25 (24): 8089–94. PMID 3026468. 
  • Fiaschi T, Raugei G, Marzocchini R, et al. (1995). "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase.". FEBS Lett. 367 (2): 145–8. PMID 7796909. 
  • Fiaschi T, Marzella R, Veggi D, et al. (1998). "Assignment of the human erythrocyte acylphosphatase gene (ACYP1) to chromosome band 14q24.3.". Cytogenet. Cell Genet. 81 (3-4): 235–6. PMID 9730610. 
  • Paoli P, Pazzagli L, Giannoni E, et al. (2003). "A nucleophilic catalysis step is involved in the hydrolysis of aryl phosphate monoesters by human CT acylphosphatase.". J. Biol. Chem. 278 (1): 194–9. doi:10.1074/jbc.M206918200. PMID 12409302. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. 
  • Degl'Innocenti D, Marzocchini R, Malentacchi F, et al. (2004). "ACYP1 gene possesses two alternative splicing forms that induce apoptosis.". IUBMB Life 56 (1): 29–33. PMID 14992377. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
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