Actinomycin lactonase

From Wikipedia, the free encyclopedia

In enzymology, an actinomycin lactonase (EC 3.1.1.39) is an enzyme that catalyzes the chemical reaction

actinomycin + H₂O actinomycinic monolactone

Thus, the two substrates of this enzyme are actinomycin and H₂O, whereas its product is actinomycinic monolactone.

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is actinomycin lactonohydrolase.

[edit] References

• IUBMB entry for 3.1.1.39
• BRENDA references for 3.1.1.39 (Recommended.)
• PubMed references for 3.1.1.39
• PubMed Central references for 3.1.1.39
• Google Scholar references for 3.1.1.39
• Hou CT, Perlman D (1970). "Microbial transformations of peptide antibiotics. V. Purification and properties of the actinomycin lactonase from Actinoplanes missouriensis". J. Biol. Chem. 245: 1289–95. PMID 4191854. 

[edit] External links

The CAS registry number for this enzyme class is 37288-09-8.

• IUBMB entry for 3.1.1.39

• KEGG entry for 3.1.1.39

• BRENDA entry for 3.1.1.39

• NiceZyme view of 3.1.1.39

• EC2PDB: PDB structures for 3.1.1.39

• PRIAM entry for 3.1.1.39

• PUMA2 entry for 3.1.1.39

• IntEnz: Integrated Enzyme entry for 3.1.1.39

• MetaCyc entry for 3.1.1.39

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047615: actinomycin lactonase

• AMIGO entry for GO code 0047615: actinomycin lactonase